Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.

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Title: Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Authors: Moskowitz A; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Huang DT; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Hou PC; Division of Emergency Critical Care Medicine, Department of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts., Gong J; Department of Emergency Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York., Doshi PB; Department of Emergency Medicine, McGovern Medical School at UTHealth, Houston, Texas.; Division of Critical Care, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas., Grossestreuer AV; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Andersen LW; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark.; Prehospital Emergency Medical Services, Central Denmark Region, Denmark., Ngo L; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Sherwin RL; Sinai Grace Hospital, Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, Michigan., Berg KM; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Chase M; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Cocchi MN; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Division of Critical Care, Department of Anesthesia Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts., McCannon JB; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mount Auburn Hospital, Cambridge, Massachusetts., Hershey M; Division of Critical Care Medicine, South Shore Hospital, Weymouth, Massachusetts., Hilewitz A; Division of Pulmonary, Critical Care, and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York., Korotun M; Division of Pulmonary, Critical Care, and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York., Becker LB; Department of Emergency Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York., Otero RM; Beaumont Hospital, Department of Emergency Medicine, Oakland University William Beaumont School of Medicine, Beaumont, Michigan., Uduman J; Division of Pulmonary and Critical Care Medicine, Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, Michigan., Sen A; Department of Critical Care Medicine, Mayo Clinic, Phoenix, Arizona., Donnino MW; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Corporate Authors: ACTS Clinical Trial Investigators
Source: JAMA [JAMA] 2020 Aug 18; Vol. 324 (7), pp. 642-650.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
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Department of Emergency Medicine, McGovern Medical School at UTHealth, Houston, Texas.; Division of Critical Care, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Grossestreuer+AV%22">Grossestreuer AV</searchLink>; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Andersen+LW%22">Andersen LW</searchLink>; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark.; Prehospital Emergency Medical Services, Central Denmark Region, Denmark.<br /><searchLink fieldCode="AU" term="%22Ngo+L%22">Ngo L</searchLink>; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Sherwin+RL%22">Sherwin RL</searchLink>; Sinai Grace Hospital, Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Berg+KM%22">Berg KM</searchLink>; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Chase+M%22">Chase M</searchLink>; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Cocchi+MN%22">Cocchi MN</searchLink>; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Division of Critical Care, Department of Anesthesia Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22McCannon+JB%22">McCannon JB</searchLink>; 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Beaumont Hospital, Department of Emergency Medicine, Oakland University William Beaumont School of Medicine, Beaumont, Michigan.<br /><searchLink fieldCode="AU" term="%22Uduman+J%22">Uduman J</searchLink>; Division of Pulmonary and Critical Care Medicine, Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Sen+A%22">Sen A</searchLink>; Department of Critical Care Medicine, Mayo Clinic, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Donnino+MW%22">Donnino MW</searchLink>; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
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