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KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden.

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Title: KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden.
Authors: Marinelli D; Department of Clinical and Molecular Medicine, Oncology Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy., Mazzotta M; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Scalera S; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Terrenato I; Biostatistics-Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Sperati F; Biostatistics Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy., D'Ambrosio L; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Pallocca M; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Corleone G; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Krasniqi E; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Pizzuti L; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Barba M; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Carpano S; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Vici P; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Filetti M; Department of Clinical and Molecular Medicine, Oncology Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy., Giusti R; Medical Oncology Unit, Sant'Andrea Hospital, Rome, Italy., Vecchione A; Department of Clinical and Molecular Medicine, Pathology Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy., Occhipinti M; Medical Oncology Unit B, Policlinico Umberto I, Sapienza University, Rome, Italy., Gelibter A; Medical Oncology Unit B, Policlinico Umberto I, Sapienza University, Rome, Italy., Botticelli A; Medical Oncology Unit B, Policlinico Umberto I, Sapienza University, Rome, Italy., De Nicola F; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Ciuffreda L; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Goeman F; Oncogenomic and Epigenetic Unit, IRCCS 'Regina Elena' National Cancer Institute, Rome, Italy., Gallo E; Department of Pathology, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Visca P; Department of Pathology, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Pescarmona E; Department of Pathology, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Fanciulli M; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy., De Maria R; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of General Pathology, Università Cattolica del Sacro Cuore, Rome, Italy., Marchetti P; Department of Clinical and Molecular Medicine, Oncology Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy; Medical Oncology Unit B, Policlinico Umberto I, Sapienza University, Rome, Italy., Ciliberto G; Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Maugeri-Saccà M; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address: marcello.maugerisacca@ifo.gov.it.
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2020 Dec; Vol. 31 (12), pp. 1746-1754. Date of Electronic Publication: 2020 Aug 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
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  Data: KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden.
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  Data: <searchLink fieldCode="AU" term="%22Marinelli+D%22">Marinelli D</searchLink>; Department of Clinical and Molecular Medicine, Oncology Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzotta+M%22">Mazzotta M</searchLink>; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Scalera+S%22">Scalera S</searchLink>; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Terrenato+I%22">Terrenato I</searchLink>; Biostatistics-Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Sperati+F%22">Sperati F</searchLink>; Biostatistics Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22D'Ambrosio+L%22">D'Ambrosio L</searchLink>; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pallocca+M%22">Pallocca M</searchLink>; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Corleone+G%22">Corleone G</searchLink>; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Krasniqi+E%22">Krasniqi E</searchLink>; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pizzuti+L%22">Pizzuti L</searchLink>; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Barba+M%22">Barba M</searchLink>; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Carpano+S%22">Carpano S</searchLink>; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vici+P%22">Vici P</searchLink>; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Filetti+M%22">Filetti M</searchLink>; Department of Clinical and Molecular Medicine, Oncology Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giusti+R%22">Giusti R</searchLink>; Medical Oncology Unit, Sant'Andrea Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vecchione+A%22">Vecchione A</searchLink>; Department of Clinical and Molecular Medicine, Pathology Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Occhipinti+M%22">Occhipinti M</searchLink>; Medical Oncology Unit B, Policlinico Umberto I, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gelibter+A%22">Gelibter A</searchLink>; Medical Oncology Unit B, Policlinico Umberto I, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Botticelli+A%22">Botticelli A</searchLink>; Medical Oncology Unit B, Policlinico Umberto I, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Nicola+F%22">De Nicola F</searchLink>; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ciuffreda+L%22">Ciuffreda L</searchLink>; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Goeman+F%22">Goeman F</searchLink>; Oncogenomic and Epigenetic Unit, IRCCS 'Regina Elena' National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gallo+E%22">Gallo E</searchLink>; Department of Pathology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Visca+P%22">Visca P</searchLink>; Department of Pathology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pescarmona+E%22">Pescarmona E</searchLink>; Department of Pathology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fanciulli+M%22">Fanciulli M</searchLink>; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Maria+R%22">De Maria R</searchLink>; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of General Pathology, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Marchetti+P%22">Marchetti P</searchLink>; Department of Clinical and Molecular Medicine, Oncology Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy; Medical Oncology Unit B, Policlinico Umberto I, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ciliberto+G%22">Ciliberto G</searchLink>; Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Maugeri-Saccà+M%22">Maugeri-Saccà M</searchLink>; Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address: marcello.maugerisacca@ifo.gov.it.
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  Data: <searchLink fieldCode="JN" term="%229007735%22">Annals of oncology : official journal of the European Society for Medical Oncology</searchLink> [Ann Oncol] 2020 Dec; Vol. 31 (12), pp. 1746-1754. <i>Date of Electronic Publication: </i>2020 Aug 28.
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