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Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.

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Title: Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
Authors: Gout J; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Perkhofer L; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Morawe M; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Arnold F; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Ihle M; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany., Biber S; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany., Lange S; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, Munich, Germany.; Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany., Roger E; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Kraus JM; Institute of Medical Systems Biology, Ulm University, Ulm, Germany., Stifter K; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Hahn SA; Department of Molecular GI Oncology, Faculty of Medicine, Ruhr University Bochum, Bochum, Germany., Zamperone A; Department of Surgery, NYU Langone Health, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Engleitner T; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, Munich, Germany., Müller M; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Walter K; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Rodriguez-Aznar E; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Sainz B Jr; Cancer Stem Cell and Tumor Microenvironment Group, Instituto de Investigaciones Biomédicas 'Alberto Sols' CSIC-UAM, Madrid, Spain.; Cancer Stem Cell and Fibroinflammatory Microenvironment Group, Area 3 - Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain., Hermann PC; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Hessmann E; Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Göttingen, Germany., Müller S; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, Munich, Germany., Azoitei N; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Lechel A; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Liebau S; Institute of Neuroanatomy & Developmental Biology INDB, Eberhard Karls Universitat Tübingen, Tübingen, Germany., Wagner M; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Simeone DM; Department of Surgery, NYU Langone Health, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Department of Pathology, NYU Langone Health, New York, NY, USA., Kestler HA; Institute of Medical Systems Biology, Ulm University, Ulm, Germany., Seufferlein T; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Wiesmüller L; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany., Rad R; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, Munich, Germany.; Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Frappart PO; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.; Institute of Toxicology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Kleger A; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany alexander.kleger@uni-ulm.de.
Source: Gut [Gut] 2021 Apr; Vol. 70 (4), pp. 743-760. Date of Electronic Publication: 2020 Sep 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Gout+J%22">Gout J</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Perkhofer+L%22">Perkhofer L</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Morawe+M%22">Morawe M</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Arnold+F%22">Arnold F</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Ihle+M%22">Ihle M</searchLink>; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Biber+S%22">Biber S</searchLink>; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Lange+S%22">Lange S</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, Munich, Germany.; Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Roger+E%22">Roger E</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Kraus+JM%22">Kraus JM</searchLink>; Institute of Medical Systems Biology, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Stifter+K%22">Stifter K</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hahn+SA%22">Hahn SA</searchLink>; Department of Molecular GI Oncology, Faculty of Medicine, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Zamperone+A%22">Zamperone A</searchLink>; Department of Surgery, NYU Langone Health, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Engleitner+T%22">Engleitner T</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+M%22">Müller M</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Walter+K%22">Walter K</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Aznar+E%22">Rodriguez-Aznar E</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Sainz+B+Jr%22">Sainz B Jr</searchLink>; Cancer Stem Cell and Tumor Microenvironment Group, Instituto de Investigaciones Biomédicas 'Alberto Sols' CSIC-UAM, Madrid, Spain.; Cancer Stem Cell and Fibroinflammatory Microenvironment Group, Area 3 - Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Hermann+PC%22">Hermann PC</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hessmann+E%22">Hessmann E</searchLink>; Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+S%22">Müller S</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Azoitei+N%22">Azoitei N</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Lechel+A%22">Lechel A</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Liebau+S%22">Liebau S</searchLink>; Institute of Neuroanatomy & Developmental Biology INDB, Eberhard Karls Universitat Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+M%22">Wagner M</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Simeone+DM%22">Simeone DM</searchLink>; Department of Surgery, NYU Langone Health, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Department of Pathology, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kestler+HA%22">Kestler HA</searchLink>; Institute of Medical Systems Biology, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Seufferlein+T%22">Seufferlein T</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Wiesmüller+L%22">Wiesmüller L</searchLink>; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Rad+R%22">Rad R</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, Munich, Germany.; Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Frappart+PO%22">Frappart PO</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.; Institute of Toxicology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Kleger+A%22">Kleger A</searchLink>; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany alexander.kleger@uni-ulm.de.
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