PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition.
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| Title: | PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition. |
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| Authors: | Spangle JM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; jennifer.spangle@emory.edu thomas_roberts@dfci.harvard.edu., Von T; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115., Pavlick DC; Foundation Medicine, Cambridge, MA 02141., Khotimsky A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115., Zhao JJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115., Roberts TM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; jennifer.spangle@emory.edu thomas_roberts@dfci.harvard.edu.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 29; Vol. 117 (39), pp. 24427-24433. Date of Electronic Publication: 2020 Sep 14. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 32929011 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Spangle+JM%22">Spangle JM</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; jennifer.spangle@emory.edu thomas&#95;roberts@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Von+T%22">Von T</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Pavlick+DC%22">Pavlick DC</searchLink>; Foundation Medicine, Cambridge, MA 02141.<br /><searchLink fieldCode="AU" term="%22Khotimsky+A%22">Khotimsky A</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Zhao+JJ%22">Zhao JJ</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Roberts+TM%22">Roberts TM</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; jennifer.spangle@emory.edu thomas&#95;roberts@dfci.harvard.edu.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2020 Sep 29; Vol. 117 (39), pp. 24427-24433. <i>Date of Electronic Publication: </i>2020 Sep 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22National+Academy+of+Sciences%22">National Academy of Sciences </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7505876 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1091-6490 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200278424%22">00278424 </searchLink><i>NLM ISO Abbreviation: </i>Proc Natl Acad Sci U S A <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32929011 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2000060117 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 24427 Titles: – TitleFull: PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Spangle JM – PersonEntity: Name: NameFull: Von T – PersonEntity: Name: NameFull: Pavlick DC – PersonEntity: Name: NameFull: Khotimsky A – PersonEntity: Name: NameFull: Zhao JJ – PersonEntity: Name: NameFull: Roberts TM IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 09 Text: 2020 Sep 29 Type: published Y: 2020 Identifiers: – Type: issn-electronic Value: 1091-6490 Numbering: – Type: volume Value: 117 – Type: issue Value: 39 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
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