PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition.
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| Title: | PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition. |
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| Authors: | Spangle JM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; jennifer.spangle@emory.edu thomas_roberts@dfci.harvard.edu., Von T; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115., Pavlick DC; Foundation Medicine, Cambridge, MA 02141., Khotimsky A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115., Zhao JJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115., Roberts TM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; jennifer.spangle@emory.edu thomas_roberts@dfci.harvard.edu.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 29; Vol. 117 (39), pp. 24427-24433. Date of Electronic Publication: 2020 Sep 14. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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