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Expression of R-Spondin 1 in ApcMin/+ Mice Suppresses Growth of Intestinal Adenomas by Altering Wnt and Transforming Growth Factor Beta Signaling.

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Title: Expression of R-Spondin 1 in ApcMin/+ Mice Suppresses Growth of Intestinal Adenomas by Altering Wnt and Transforming Growth Factor Beta Signaling.
Authors: Lähde M; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Heino S; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Högström J; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts., Kaijalainen S; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Anisimov A; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Flanagan D; Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Kallio P; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Leppänen VM; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland., Ristimäki A; Department of Pathology, HUSLAB, HUS Diagnostic Center, Helsinki University Hospital; Medicum and Applied Tumor Genomics, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Ritvos O; Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Wu K; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York., Tammela T; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York; Cell and Developmental Biology, Weill-Cornell Medical College, New York, New York., Hodder M; Cancer Research UK Beatson Institute, Glasgow, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Alitalo K; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland. Electronic address: kari.alitalo@helsinki.fi.
Source: Gastroenterology [Gastroenterology] 2021 Jan; Vol. 160 (1), pp. 245-259. Date of Electronic Publication: 2020 Sep 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
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  Data: Expression of R-Spondin 1 in Apc<superscript>Min/+</superscript> Mice Suppresses Growth of Intestinal Adenomas by Altering Wnt and Transforming Growth Factor Beta Signaling.
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  Data: <searchLink fieldCode="AU" term="%22Lähde+M%22">Lähde M</searchLink>; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Heino+S%22">Heino S</searchLink>; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Högström+J%22">Högström J</searchLink>; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kaijalainen+S%22">Kaijalainen S</searchLink>; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Anisimov+A%22">Anisimov A</searchLink>; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Flanagan+D%22">Flanagan D</searchLink>; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kallio+P%22">Kallio P</searchLink>; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Leppänen+VM%22">Leppänen VM</searchLink>; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Ristimäki+A%22">Ristimäki A</searchLink>; Department of Pathology, HUSLAB, HUS Diagnostic Center, Helsinki University Hospital; Medicum and Applied Tumor Genomics, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Ritvos+O%22">Ritvos O</searchLink>; Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Wu+K%22">Wu K</searchLink>; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Tammela+T%22">Tammela T</searchLink>; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York; Cell and Developmental Biology, Weill-Cornell Medical College, New York, New York.<br /><searchLink fieldCode="AU" term="%22Hodder+M%22">Hodder M</searchLink>; Cancer Research UK Beatson Institute, Glasgow, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sansom+OJ%22">Sansom OJ</searchLink>; Cancer Research UK Beatson Institute, Glasgow, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Alitalo+K%22">Alitalo K</searchLink>; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland. Electronic address: kari.alitalo@helsinki.fi.
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  Data: <searchLink fieldCode="JN" term="%220374630%22">Gastroenterology</searchLink> [Gastroenterology] 2021 Jan; Vol. 160 (1), pp. 245-259. <i>Date of Electronic Publication: </i>2020 Sep 14.
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