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The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution.

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Title: The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution.
Authors: Ballhausen A; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Przybilla MJ; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Jendrusch M; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Haupt S; Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany., Pfaffendorf E; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Seidler F; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Witt J; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Hernandez Sanchez A; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Urban K; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Draxlbauer M; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Krausert S; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Ahadova A; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Kalteis MS; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Pfuderer PL; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Heid D; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Stichel D; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Gebert J; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Bonsack M; Immunotherapy and Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Vaccine Design, German Center for Infection Research (DZIF), partner site Heidelberg, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Schott S; Department of Obstetrics and Gynecology, University Hospital Heidelberg, Heidelberg, Germany., Bläker H; Institute of Pathology, University Hospital Leipzig, Leipzig, Germany., Seppälä T; Department of Gastrointestinal Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Mecklin JP; Department of Education and Research, Central Finland Central Hospital, Jyväskylä, Finland.; Department of Sports and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Ten Broeke S; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Nielsen M; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Heuveline V; Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany., Krzykalla J; Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Benner A; Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Riemer AB; Immunotherapy and Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Vaccine Design, German Center for Infection Research (DZIF), partner site Heidelberg, Heidelberg, Germany., von Knebel Doeberitz M; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany., Kloor M; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany. matthias.kloor@med.uni-heidelberg.de.; Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany. matthias.kloor@med.uni-heidelberg.de.; Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL, Heidelberg, Germany. matthias.kloor@med.uni-heidelberg.de.
Source: Nature communications [Nat Commun] 2020 Sep 21; Vol. 11 (1), pp. 4740. Date of Electronic Publication: 2020 Sep 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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