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Extensive heterogeneity in somatic mutation and selection in the human bladder.

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Title: Extensive heterogeneity in somatic mutation and selection in the human bladder.
Authors: Lawson ARJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Abascal F; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Coorens THH; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Hooks Y; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., O'Neill L; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Latimer C; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Raine K; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Sanders MA; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Department of Hematology, Erasmus University Medical Center, Rotterdam 3015 GD, Netherlands., Warren AY; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Mahbubani KTA; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Bareham B; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Butler TM; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Harvey LMR; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Cagan A; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Menzies A; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Moore L; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Colquhoun AJ; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Turner W; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Thomas B; The Royal Melbourne Hospital, Parkville, Victoria 3010, Australia.; Department of Surgery, The University of Melbourne, Parkville, Victoria 3010, Australia., Gnanapragasam V; Academic Urology Group, Department of Surgery and Oncology, University of Cambridge, Cambridge CB2 0QQ, UK.; Cambridge Urology Translational Research and Clinical Trials Office, University of Cambridge CB2 0QQ, UK., Williams N; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Rassl DM; Department of Pathology, Royal Papworth Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0AY, UK., Vöhringer H; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK., Zumalave S; Mobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain., Nangalia J; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Tubío JMC; Mobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.; Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.; The Biomedical Research Centre (CINBIO), University of Vigo, Vigo 36310, Spain., Gerstung M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Stratton MR; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK., Mitchell TJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Martincorena I; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK. im3@sanger.ac.uk.
Source: Science (New York, N.Y.) [Science] 2020 Oct 02; Vol. 370 (6512), pp. 75-82.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.; The Biomedical Research Centre (CINBIO), University of Vigo, Vigo 36310, Spain.<br /><searchLink fieldCode="AU" term="%22Gerstung+M%22">Gerstung M</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK.<br /><searchLink fieldCode="AU" term="%22Saeb-Parsy+K%22">Saeb-Parsy K</searchLink>; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Stratton+MR%22">Stratton MR</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+PJ%22">Campbell PJ</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; 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