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Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection.

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Title: Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection.
Authors: Hughes SM; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA., Levy CN; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA., Calienes FL; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Stekler JD; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Pandey U; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA., Vojtech L; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA., Berard AR; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada., Birse K; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA., Noël-Romas L; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA., Richardson B; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Golden JB; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Cartwright M; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Collier AC; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA., Stevens CE; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA., Curlin ME; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.; Department of Medicine, Division of Infectious Diseases, Oregon Health and Sciences University, Portland, OR, USA., Holtz TH; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand., Mugo N; Partners in Health Research and Development, Kenya Medical Research Institute, Thika, Kenya.; Center for Clinical Research (CCR), Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.; Department of Global Health, University of Washington, Seattle, WA, USA., Irungu E; Partners in Health Research and Development, Kenya Medical Research Institute, Thika, Kenya., Katabira E; Infectious Disease Institute, Makerere University, Kampala, Uganda., Muwonge T; Infectious Disease Institute, Makerere University, Kampala, Uganda., Lama JR; Asociación Civil Impacta Salud y Educación, Lima, Peru., Baeten JM; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Burgener A; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA.; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden., Lingappa JR; Department of Pediatrics, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Mackelprang R; Department of Global Health, University of Washington, Seattle, WA, USA., McGowan I; Orion Biotechnology, Ottawa, ON, Canada.; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Cranston RD; Department of Infectious Diseases and Dermatology, University of Barcelona, Barcelona, Spain., Cameron MJ; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Hladik F; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Source: Cell reports. Medicine [Cell Rep Med] 2020 Sep 22; Vol. 1 (6), pp. 100096. Date of Electronic Publication: 2020 Sep 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med
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  Data: Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection.
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Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Berard+AR%22">Berard AR</searchLink>; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Birse+K%22">Birse K</searchLink>; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Noël-Romas+L%22">Noël-Romas L</searchLink>; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Richardson+B%22">Richardson B</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Golden+JB%22">Golden JB</searchLink>; 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Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.<br /><searchLink fieldCode="AU" term="%22Mugo+N%22">Mugo N</searchLink>; Partners in Health Research and Development, Kenya Medical Research Institute, Thika, Kenya.; Center for Clinical Research (CCR), Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.; Department of Global Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Irungu+E%22">Irungu E</searchLink>; Partners in Health Research and Development, Kenya Medical Research Institute, Thika, Kenya.<br /><searchLink fieldCode="AU" term="%22Katabira+E%22">Katabira E</searchLink>; Infectious Disease Institute, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Muwonge+T%22">Muwonge T</searchLink>; Infectious Disease Institute, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Lama+JR%22">Lama JR</searchLink>; Asociación Civil Impacta Salud y Educación, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Baeten+JM%22">Baeten JM</searchLink>; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Burgener+A%22">Burgener A</searchLink>; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA.; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Lingappa+JR%22">Lingappa JR</searchLink>; Department of Pediatrics, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22McElrath+MJ%22">McElrath MJ</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mackelprang+R%22">Mackelprang R</searchLink>; Department of Global Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22McGowan+I%22">McGowan I</searchLink>; Orion Biotechnology, Ottawa, ON, Canada.; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cranston+RD%22">Cranston RD</searchLink>; Department of Infectious Diseases and Dermatology, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cameron+MJ%22">Cameron MJ</searchLink>; 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