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Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma: a randomized phase 2 trial.

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Title: Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma: a randomized phase 2 trial.
Authors: Algazi AP; University of California, San Francisco, San Francisco, CA, USA. alain.algazi@ucsf.edu., Othus M; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Daud AI; University of California, San Francisco, San Francisco, CA, USA., Lo RS; University of California, Los Angeles, Los Angeles, CA, USA., Mehnert JM; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Truong TG; Kaiser Permanente Northern California, Vallejo, CA, USA., Conry R; University of Alabama, Birmingham, Birmingham, AL, USA., Kendra K; Ohio State University, Columbus, OH, USA., Doolittle GC; University of Kansas Hospital-Westwood Cancer Center, Westwood, KS, USA., Clark JI; Loyola University, Chicago, IL, USA., Messino MJ; Messino Cancer Centers-Asheville/ Southeast COR NCORP/Asheville, Asheville, NC, USA., Moore DF Jr; Cancer Center of Kansas/Wichita NCORP, Wichita, KS, USA., Lao C; University of Michigan, Ann Arbor, MI, USA., Faller BA; Missouri Baptist Medical Center Cancer Center/Heartland NCORP, St Louis, MO, USA., Govindarajan R; University of Arkansas, Little Rock, AR, USA., Harker-Murray A; Froedtert and the Medical College of Wisconsin, Milwaukee, WI, USA., Dreisbach L; Eisenhower Medical Center, Rancho Mirage, CA, USA., Moon J; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Grossmann KF; Huntsman Cancer Institute, Salt Lake City, UT, USA., Ribas A; University of California, Los Angeles, Los Angeles, CA, USA.
Source: Nature medicine [Nat Med] 2020 Oct; Vol. 26 (10), pp. 1564-1568. Date of Electronic Publication: 2020 Oct 05.
Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma: a randomized phase 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Algazi+AP%22">Algazi AP</searchLink>; University of California, San Francisco, San Francisco, CA, USA. alain.algazi@ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Othus+M%22">Othus M</searchLink>; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Daud+AI%22">Daud AI</searchLink>; University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lo+RS%22">Lo RS</searchLink>; University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mehnert+JM%22">Mehnert JM</searchLink>; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Truong+TG%22">Truong TG</searchLink>; Kaiser Permanente Northern California, Vallejo, CA, USA.<br /><searchLink fieldCode="AU" term="%22Conry+R%22">Conry R</searchLink>; University of Alabama, Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Kendra+K%22">Kendra K</searchLink>; Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Doolittle+GC%22">Doolittle GC</searchLink>; University of Kansas Hospital-Westwood Cancer Center, Westwood, KS, USA.<br /><searchLink fieldCode="AU" term="%22Clark+JI%22">Clark JI</searchLink>; Loyola University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Messino+MJ%22">Messino MJ</searchLink>; Messino Cancer Centers-Asheville/ Southeast COR NCORP/Asheville, Asheville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Moore+DF+Jr%22">Moore DF Jr</searchLink>; Cancer Center of Kansas/Wichita NCORP, Wichita, KS, USA.<br /><searchLink fieldCode="AU" term="%22Lao+C%22">Lao C</searchLink>; University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Faller+BA%22">Faller BA</searchLink>; Missouri Baptist Medical Center Cancer Center/Heartland NCORP, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Govindarajan+R%22">Govindarajan R</searchLink>; University of Arkansas, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Harker-Murray+A%22">Harker-Murray A</searchLink>; Froedtert and the Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Dreisbach+L%22">Dreisbach L</searchLink>; Eisenhower Medical Center, Rancho Mirage, CA, USA.<br /><searchLink fieldCode="AU" term="%22Moon+J%22">Moon J</searchLink>; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Grossmann+KF%22">Grossmann KF</searchLink>; Huntsman Cancer Institute, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Ribas+A%22">Ribas A</searchLink>; University of California, Los Angeles, Los Angeles, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2020 Oct; Vol. 26 (10), pp. 1564-1568. <i>Date of Electronic Publication: </i>2020 Oct 05.
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