A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.
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| Title: | A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. |
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| Authors: | Pflug A; Structure, Biophysics and Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K., Schimpl M; Structure, Biophysics and Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K., Nissink JWM; Oncology R&D, AstraZeneca, Cambridge, U.K., Overman RC; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K., Rawlins PB; Structure, Biophysics and Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K., Truman C; Mechanistic Biology and Profiling, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K., Underwood E; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K., Warwicker J; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K., Winter-Holt J; Oncology R&D, AstraZeneca, Cambridge, U.K., McCoull W; Oncology R&D, AstraZeneca, Cambridge, U.K. |
| Source: | The Biochemical journal [Biochem J] 2020 Nov 27; Vol. 477 (22), pp. 4443-4452. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 33119085 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Pflug+A%22">Pflug A</searchLink>; Structure, Biophysics and Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K.<br /><searchLink fieldCode="AU" term="%22Schimpl+M%22">Schimpl M</searchLink>; Structure, Biophysics and Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K.<br /><searchLink fieldCode="AU" term="%22Nissink+JWM%22">Nissink JWM</searchLink>; Oncology R&D, AstraZeneca, Cambridge, U.K.<br /><searchLink fieldCode="AU" term="%22Overman+RC%22">Overman RC</searchLink>; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K.<br /><searchLink fieldCode="AU" term="%22Rawlins+PB%22">Rawlins PB</searchLink>; Structure, Biophysics and Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K.<br /><searchLink fieldCode="AU" term="%22Truman+C%22">Truman C</searchLink>; Mechanistic Biology and Profiling, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K.<br /><searchLink fieldCode="AU" term="%22Underwood+E%22">Underwood E</searchLink>; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K.<br /><searchLink fieldCode="AU" term="%22Warwicker+J%22">Warwicker J</searchLink>; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, U.K.<br /><searchLink fieldCode="AU" term="%22Winter-Holt+J%22">Winter-Holt J</searchLink>; Oncology R&D, AstraZeneca, Cambridge, U.K.<br /><searchLink fieldCode="AU" term="%22McCoull+W%22">McCoull W</searchLink>; Oncology R&D, AstraZeneca, Cambridge, U.K. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%222984726R%22">The Biochemical journal</searchLink> [Biochem J] 2020 Nov 27; Vol. 477 (22), pp. 4443-4452. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Published+by+Portland+Press+on+behalf+of+the+Biochemical+Society%22">Published by Portland Press on behalf of the Biochemical Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2984726R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1470-8728 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202646021%22">02646021 </searchLink><i>NLM ISO Abbreviation: </i>Biochem J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=33119085 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1042/BCJ20200735 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 4443 Titles: – TitleFull: A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pflug A – PersonEntity: Name: NameFull: Schimpl M – PersonEntity: Name: NameFull: Nissink JWM – PersonEntity: Name: NameFull: Overman RC – PersonEntity: Name: NameFull: Rawlins PB – PersonEntity: Name: NameFull: Truman C – PersonEntity: Name: NameFull: Underwood E – PersonEntity: Name: NameFull: Warwicker J – PersonEntity: Name: NameFull: Winter-Holt J – PersonEntity: Name: NameFull: McCoull W IsPartOfRelationships: – BibEntity: Dates: – D: 27 M: 11 Text: 2020 Nov 27 Type: published Y: 2020 Identifiers: – Type: issn-electronic Value: 1470-8728 Numbering: – Type: volume Value: 477 – Type: issue Value: 22 Titles: – TitleFull: The Biochemical journal Type: main |
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