Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors.
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| Title: | Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors. |
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| Authors: | Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt. Electronic address: mamdouh.fawzi@pharm.sohag.edu.eg., Marzouk AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, Egypt., Nafady A; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., El-Gamal DA; Histology Department, Faculty of Medicine, Assiut University, 71526 Assiut, Egypt., Allam RM; Pharmacology Department, National Research Centre, Giza 11865, Egypt., Abuo-Rahma GEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., El Subbagh HI; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt., Moustafa AH; Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt. |
| Source: | Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104439. Date of Electronic Publication: 2020 Oct 28. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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