Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
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| Title: | Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. |
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| Authors: | Alleyne C; Discovery Pharmaceutical Sciences, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Amin RP; Safety Assessment, Merck & Comapny, Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States., Bhatt B; Safety Assessment, Merck & Comapny, Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States., Bianchi E; IRBM S.p.A., Via Pontina km 30600, Pomezia, Rome 00071, Italy., Blain JC; UCB Ra Pharma, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Boyer N; UCB Ra Pharma, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Branca D; IRBM S.p.A., Via Pontina km 30600, Pomezia, Rome 00071, Italy., Embrey MW; Departments of Medicinal Chemistry, Merck & Company, Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States., Ha SN; Modeling and Informatics, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Jette K; UCB Ra Pharma, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Johns DG; Discovery Biology, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Kerekes AD; Departments of Medicinal Chemistry, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Koeplinger KA; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Company, Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States., LaPlaca D; UCB Ra Pharma, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Li N; Safety Assessment, Merck & Comapny, Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States., Murphy B; Discovery Biology, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Orth P; Structural Sciences, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Ricardo A; UCB Ra Pharma, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Salowe S; Discovery Biology, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Seyb K; UCB Ra Pharma, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Shahripour A; Departments of Medicinal Chemistry, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Stringer JR; UCB Ra Pharma, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Sun Y; UCB Ra Pharma, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Tracy R; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Company, Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States., Wu C; Departments of Medicinal Chemistry, Merck & Company, Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States., Xiong Y; Departments of Medicinal Chemistry, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Youm H; Departments of Medicinal Chemistry, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Zokian HJ; Discovery Biology, Merck & Company, Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Tucker TJ; Departments of Medicinal Chemistry, Merck & Company, Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2020 Nov 25; Vol. 63 (22), pp. 13796-13824. Date of Electronic Publication: 2020 Nov 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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