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Pasotuxizumab, a BiTE® immune therapy for castration-resistant prostate cancer: Phase I, dose-escalation study findings.

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Title: Pasotuxizumab, a BiTE® immune therapy for castration-resistant prostate cancer: Phase I, dose-escalation study findings.
Authors: Hummel HD; Translational Oncology/Early Clinical Trial Unit (ECTU), Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany., Kufer P; Research and Development, Amgen Research Munich GmbH, Staffelseestr. 2, 81477, Munich, Germany., Grüllich C; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Medical Center, Heidelberg, Germany; & Department of Oncology & Hematology, University Hospital Dresden, Haus 27, Fetscherstr. 74, 01307 Dresden, Germany., Seggewiss-Bernhardt R; Translational Oncology/Early Clinical Trial Unit (ECTU), Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany.; Medizinische Klinik V, Sozialstiftung Bamberg, Buger Str. 80, 96049, Bamberg, Germany., Deschler-Baier B; Translational Oncology, Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany., Chatterjee M; Translational Oncology/Early Clinical Trial Unit (ECTU), Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany., Goebeler ME; Translational Oncology/Early Clinical Trial Unit (ECTU), Medizinische Klinik II, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany., Miller K; Department of Urology, Charité Universitätsmedizin Berlin, Charitéplatz. 1, 10117, Berlin, Germany., de Santis M; Department of Urology, Charité Universitätsmedizin Berlin, Charitéplatz. 1, 10117, Berlin, Germany.; Department of Urology, Medical University Vienna, Währinger Gürtel 18-20; 1090 Vienna, Austria., Loidl W; Department of Urology, Ordensklinikum Linz GmbH Elisabethinen, Fadingerstr. 1, 4020, Linz, Austria., Dittrich C; Applied Cancer Research-Institution for Translational Research Vienna (ACR-ITR VIEnna) & Center for Oncology & Hematology, Kaiser Franz Josef-Spital, Bernardgasse 24/2, 1070, Vienna, Austria., Buck A; Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, D-97080, Würzburg, Germany., Lapa C; Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, D-97080, Würzburg, Germany.; Nuclear Medicine, Medical Faculty, University of Augsburg, Stenglinstr. 2, 86156 Augsburg, Germany., Thurner A; Department of Diagnostic & Interventional Radiology, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080, Würzburg, Germany., Wittemer-Rump S; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany., Koca G; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany., Boix O; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany., Döcke WD; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany., Finnern R; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany., Kusi H; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany., Ajavon-Hartmann A; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany., Stienen S; Research and Development, Amgen Research Munich GmbH, Staffelseestr. 2, 81477, Munich, Germany., Sayehli CM; Translational Oncology/Early Clinical Trial Unit (ECTU), Medizinische Klinik II, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany., Polat B; Department of Radiation Oncology, University Hospital Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany., Bargou RC; Translational Oncology, Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany.
Source: Immunotherapy [Immunotherapy] 2021 Feb; Vol. 13 (2), pp. 125-141. Date of Electronic Publication: 2020 Nov 10.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-7448 (Electronic) Linking ISSN: 1750743X NLM ISO Abbreviation: Immunotherapy Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Pasotuxizumab, a BiTE<superscript>®</superscript> immune therapy for castration-resistant prostate cancer: Phase I, dose-escalation study findings.
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  Data: <searchLink fieldCode="AU" term="%22Hummel+HD%22">Hummel HD</searchLink>; Translational Oncology/Early Clinical Trial Unit (ECTU), Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kufer+P%22">Kufer P</searchLink>; Research and Development, Amgen Research Munich GmbH, Staffelseestr. 2, 81477, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Grüllich+C%22">Grüllich C</searchLink>; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Medical Center, Heidelberg, Germany; & Department of Oncology & Hematology, University Hospital Dresden, Haus 27, Fetscherstr. 74, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Seggewiss-Bernhardt+R%22">Seggewiss-Bernhardt R</searchLink>; Translational Oncology/Early Clinical Trial Unit (ECTU), Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany.; Medizinische Klinik V, Sozialstiftung Bamberg, Buger Str. 80, 96049, Bamberg, Germany.<br /><searchLink fieldCode="AU" term="%22Deschler-Baier+B%22">Deschler-Baier B</searchLink>; Translational Oncology, Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Chatterjee+M%22">Chatterjee M</searchLink>; Translational Oncology/Early Clinical Trial Unit (ECTU), Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Goebeler+ME%22">Goebeler ME</searchLink>; Translational Oncology/Early Clinical Trial Unit (ECTU), Medizinische Klinik II, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Miller+K%22">Miller K</searchLink>; Department of Urology, Charité Universitätsmedizin Berlin, Charitéplatz. 1, 10117, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22de+Santis+M%22">de Santis M</searchLink>; Department of Urology, Charité Universitätsmedizin Berlin, Charitéplatz. 1, 10117, Berlin, Germany.; Department of Urology, Medical University Vienna, Währinger Gürtel 18-20; 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Loidl+W%22">Loidl W</searchLink>; Department of Urology, Ordensklinikum Linz GmbH Elisabethinen, Fadingerstr. 1, 4020, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Dittrich+C%22">Dittrich C</searchLink>; Applied Cancer Research-Institution for Translational Research Vienna (ACR-ITR VIEnna) & Center for Oncology & Hematology, Kaiser Franz Josef-Spital, Bernardgasse 24/2, 1070, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Buck+A%22">Buck A</searchLink>; Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, D-97080, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lapa+C%22">Lapa C</searchLink>; Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, D-97080, Würzburg, Germany.; Nuclear Medicine, Medical Faculty, University of Augsburg, Stenglinstr. 2, 86156 Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Thurner+A%22">Thurner A</searchLink>; Department of Diagnostic & Interventional Radiology, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wittemer-Rump+S%22">Wittemer-Rump S</searchLink>; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Koca+G%22">Koca G</searchLink>; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Boix+O%22">Boix O</searchLink>; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Döcke+WD%22">Döcke WD</searchLink>; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Finnern+R%22">Finnern R</searchLink>; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kusi+H%22">Kusi H</searchLink>; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ajavon-Hartmann+A%22">Ajavon-Hartmann A</searchLink>; Bayer AG, SBU Oncology, Pharmaceuticals, 13353, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stienen+S%22">Stienen S</searchLink>; Research and Development, Amgen Research Munich GmbH, Staffelseestr. 2, 81477, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sayehli+CM%22">Sayehli CM</searchLink>; Translational Oncology/Early Clinical Trial Unit (ECTU), Medizinische Klinik II, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Polat+B%22">Polat B</searchLink>; Department of Radiation Oncology, University Hospital Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bargou+RC%22">Bargou RC</searchLink>; Translational Oncology, Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101485158%22">Immunotherapy</searchLink> [Immunotherapy] 2021 Feb; Vol. 13 (2), pp. 125-141. <i>Date of Electronic Publication: </i>2020 Nov 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101485158 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1750-7448 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221750743X%22">1750743X </searchLink><i>NLM ISO Abbreviation: </i>Immunotherapy <i>Subsets: </i>MEDLINE
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