Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes.

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Title: Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes.
Authors: Sottini A; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Borgia A; Department of Biochemistry, University of Zurich, Zurich, Switzerland.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Borgia MB; Department of Biochemistry, University of Zurich, Zurich, Switzerland.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Bugge K; Structural Biology and NMR Laboratory (SBiNLab) and REPIN, Department of Biology, Ole Maaloes Vej 5, University of Copenhagen, 2200, Copenhagen, Denmark., Nettels D; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Chowdhury A; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Heidarsson PO; Department of Biochemistry, University of Zurich, Zurich, Switzerland.; Department of Biochemistry, Science Institute, University of Iceland, Dunhagi 3, 107, Reykjavík, Iceland., Zosel F; Department of Biochemistry, University of Zurich, Zurich, Switzerland.; Novo Nordisk A/S, Novo Nordisk Park, 2760, Måløv, Denmark., Best RB; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA. robert.best2@nih.gov., Kragelund BB; Structural Biology and NMR Laboratory (SBiNLab) and REPIN, Department of Biology, Ole Maaloes Vej 5, University of Copenhagen, 2200, Copenhagen, Denmark. bbk@bio.ku.dk., Schuler B; Department of Biochemistry, University of Zurich, Zurich, Switzerland. schuler@bioc.uzh.ch.; Department of Physics, University of Zurich, Zurich, Switzerland. schuler@bioc.uzh.ch.
Source: Nature communications [Nat Commun] 2020 Nov 12; Vol. 11 (1), pp. 5736. Date of Electronic Publication: 2020 Nov 12.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-020-18859-x