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ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.

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Title: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Authors: Zyryanova AF; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Kashiwagi K; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Rato C; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Harding HP; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Crespillo-Casado A; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Perera LA; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Sakamoto A; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Nishimoto M; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Yonemochi M; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Shirouzu M; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Ito T; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address: takuhiro.ito@riken.jp., Ron D; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK. Electronic address: dr360@medschl.cam.ac.uk.
Source: Molecular cell [Mol Cell] 2021 Jan 07; Vol. 81 (1), pp. 88-103.e6. Date of Electronic Publication: 2020 Nov 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4164
DOI:10.1016/j.molcel.2020.10.031