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ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.

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Title: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Authors: Zyryanova AF; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Kashiwagi K; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Rato C; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Harding HP; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Crespillo-Casado A; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Perera LA; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK., Sakamoto A; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Nishimoto M; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Yonemochi M; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Shirouzu M; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Ito T; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address: takuhiro.ito@riken.jp., Ron D; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK. Electronic address: dr360@medschl.cam.ac.uk.
Source: Molecular cell [Mol Cell] 2021 Jan 07; Vol. 81 (1), pp. 88-103.e6. Date of Electronic Publication: 2020 Nov 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
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  Data: <searchLink fieldCode="AU" term="%22Zyryanova+AF%22">Zyryanova AF</searchLink>; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Kashiwagi+K%22">Kashiwagi K</searchLink>; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Rato+C%22">Rato C</searchLink>; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Harding+HP%22">Harding HP</searchLink>; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Crespillo-Casado+A%22">Crespillo-Casado A</searchLink>; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Perera+LA%22">Perera LA</searchLink>; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Sakamoto+A%22">Sakamoto A</searchLink>; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimoto+M%22">Nishimoto M</searchLink>; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Yonemochi+M%22">Yonemochi M</searchLink>; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Shirouzu+M%22">Shirouzu M</searchLink>; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+T%22">Ito T</searchLink>; RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address: takuhiro.ito@riken.jp.<br /><searchLink fieldCode="AU" term="%22Ron+D%22">Ron D</searchLink>; Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge CB2 0XY, UK. Electronic address: dr360@medschl.cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2021 Jan 07; Vol. 81 (1), pp. 88-103.e6. <i>Date of Electronic Publication: </i>2020 Nov 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9802571 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4164 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210972765%22">10972765 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cell <i>Subsets: </i>MEDLINE
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