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Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

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Title: Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Authors: Wainger BJ; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston.; Department of Anesthesia, Critical Care & Pain Medicine, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston MA.; Harvard Stem Cell Institute, Cambridge.; Broad Institute of MIT and Harvard, Cambridge., Macklin EA; Harvard Medical School, Boston MA.; Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts., Vucic S; Department of Neurology, Westmead Hospital, Westmead, New South Wales, Australia., McIlduff CE; Harvard Medical School, Boston MA.; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Paganoni S; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston MA.; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts., Maragakis NJ; Department of Neurology, Johns Hopkins University, Baltimore, Maryland., Bedlack R; Department of Neurology, Duke University Medical Center, Durham, North Carolina., Goyal NA; Department of Neurology, University of California Irvine, Irvine., Rutkove SB; Harvard Medical School, Boston MA.; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Lange DJ; Department of Neurology, Hospital for Special Surgery, New York, New York., Rivner MH; Department of Neurology, Augusta University Medical Center, Augusta, Georgia., Goutman SA; Department of Neurology, University of Michigan, Ann Arbor., Ladha SS; Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona., Mauricio EA; Department of Neurology, Mayo Clinic, Jacksonville, Florida., Baloh RH; Department of Neurology, Cedars Sinai Medical Center, Los Angeles, California., Simmons Z; Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania., Pothier L; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston., Kassis SB; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston., La T; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston., Hall M; Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona., Evora A; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston., Klements D; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston., Hurtado A; Harvard Medical School, Boston MA.; Department of Psychiatry, Massachusetts General Hospital, Boston., Pereira JD; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston MA., Koh J; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston., Celnik PA; Department of Neurology, Johns Hopkins University, Baltimore, Maryland., Chaudhry V; Department of Neurology, Johns Hopkins University, Baltimore, Maryland., Gable K; Department of Neurology, Duke University Medical Center, Durham, North Carolina., Juel VC; Department of Neurology, Duke University Medical Center, Durham, North Carolina., Phielipp N; Department of Neurology, University of California Irvine, Irvine., Marei A; Department of Neurology, Hospital for Special Surgery, New York, New York., Rosenquist P; Department of Psychiatry, Augusta University Medical Center, Augusta, Georgia., Meehan S; School of Kinesiology, University of Michigan, Ann Arbor., Oskarsson B; Department of Neurology, Mayo Clinic, Jacksonville, Florida., Lewis RA; Department of Neurology, Cedars Sinai Medical Center, Los Angeles, California., Kaur D; Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania., Kiskinis E; Department of Neurology, Northwestern University, Chicago, Illinois., Woolf CJ; Harvard Medical School, Boston MA.; Department of Neurology, Boston Children's Hospital, Boston, Massachusetts., Eggan K; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston MA.; Harvard Stem Cell Institute, Cambridge.; Broad Institute of MIT and Harvard, Cambridge.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts., Weiss MD; Department of Neurology, University of Washington, Seattle., Berry JD; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston MA., David WS; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston MA., Davila-Perez P; Harvard Medical School, Boston MA.; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Camprodon JA; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston MA.; Department of Psychiatry, Massachusetts General Hospital, Boston., Pascual-Leone A; Harvard Medical School, Boston MA.; Marcus Institute and Center for Memory Health, Hebrew SeniorLife, Boston, Massachusetts.; Institut Guttmann, Universitat Autonoma, Barcelona, Spain., Kiernan MC; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.; Department of Neurology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia., Shefner JM; Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona., Atassi N; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston MA., Cudkowicz ME; The Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston MA.
Source: JAMA neurology [JAMA Neurol] 2021 Feb 01; Vol. 78 (2), pp. 186-196.
Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
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