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Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma.

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Title: Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma.
Authors: Straathof K; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Flutter B; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Wallace R; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Jain N; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Loka T; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Depani S; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Wright G; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Thomas S; UCL Cancer Institute, London WC1E 6DD, UK.; Autolus Ltd., London W12 7FP, UK., Cheung GW; UCL Cancer Institute, London WC1E 6DD, UK., Gileadi T; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK., Stafford S; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK., Kokalaki E; UCL Cancer Institute, London WC1E 6DD, UK., Barton J; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK., Marriott C; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Rampling D; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Ogunbiyi O; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Akarca AU; UCL Cancer Institute, London WC1E 6DD, UK., Marafioti T; UCL Cancer Institute, London WC1E 6DD, UK., Inglott S; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Gilmour K; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Al-Hajj M; Autolus Ltd., London W12 7FP, UK., Day W; Autolus Ltd., London W12 7FP, UK., McHugh K; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Biassoni L; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Sizer N; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Barton C; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Edwards D; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Dragoni I; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Silvester J; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Dyer K; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Traub S; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Elson L; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Brook S; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Westwood N; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Robson L; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Bedi A; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Howe K; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Barry A; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Duncan C; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Barone G; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Pule M; UCL Cancer Institute, London WC1E 6DD, UK. m.pule@ucl.ac.uk j.anderson@ucl.ac.uk., Anderson J; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK. m.pule@ucl.ac.uk j.anderson@ucl.ac.uk.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
Source: Science translational medicine [Sci Transl Med] 2020 Nov 25; Vol. 12 (571).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Straathof+K%22">Straathof K</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Flutter+B%22">Flutter B</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Wallace+R%22">Wallace R</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Jain+N%22">Jain N</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Loka+T%22">Loka T</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Depani+S%22">Depani S</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Wright+G%22">Wright G</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+S%22">Thomas S</searchLink>; UCL Cancer Institute, London WC1E 6DD, UK.; Autolus Ltd., London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Cheung+GW%22">Cheung GW</searchLink>; UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Gileadi+T%22">Gileadi T</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.<br /><searchLink fieldCode="AU" term="%22Stafford+S%22">Stafford S</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.<br /><searchLink fieldCode="AU" term="%22Kokalaki+E%22">Kokalaki E</searchLink>; UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Barton+J%22">Barton J</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.<br /><searchLink fieldCode="AU" term="%22Marriott+C%22">Marriott C</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Rampling+D%22">Rampling D</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Ogunbiyi+O%22">Ogunbiyi O</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Akarca+AU%22">Akarca AU</searchLink>; UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Marafioti+T%22">Marafioti T</searchLink>; UCL Cancer Institute, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Inglott+S%22">Inglott S</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Gilmour+K%22">Gilmour K</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Al-Hajj+M%22">Al-Hajj M</searchLink>; Autolus Ltd., London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Day+W%22">Day W</searchLink>; Autolus Ltd., London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22McHugh+K%22">McHugh K</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Biassoni+L%22">Biassoni L</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Sizer+N%22">Sizer N</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Barton+C%22">Barton C</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+D%22">Edwards D</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Dragoni+I%22">Dragoni I</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Silvester+J%22">Silvester J</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Dyer+K%22">Dyer K</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Traub+S%22">Traub S</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Elson+L%22">Elson L</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Brook+S%22">Brook S</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Westwood+N%22">Westwood N</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Robson+L%22">Robson L</searchLink>; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.<br /><searchLink fieldCode="AU" term="%22Bedi+A%22">Bedi A</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Howe+K%22">Howe K</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Barry+A%22">Barry A</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Duncan+C%22">Duncan C</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Barone+G%22">Barone G</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.<br /><searchLink fieldCode="AU" term="%22Pule+M%22">Pule M</searchLink>; UCL Cancer Institute, London WC1E 6DD, UK. m.pule@ucl.ac.uk j.anderson@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Anderson+J%22">Anderson J</searchLink>; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK. m.pule@ucl.ac.uk j.anderson@ucl.ac.uk.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
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