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The genetic architecture of sporadic and multiple consecutive miscarriage.

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Title: The genetic architecture of sporadic and multiple consecutive miscarriage.
Authors: Laisk T; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia. triin.laisk@ut.ee.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia. triin.laisk@ut.ee.; Competence Centre on Health Technologies, Tartu, Estonia. triin.laisk@ut.ee., Soares ALG; MRC Integrated Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Ferreira T; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK., Painter JN; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Censin JC; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Laber S; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Bacelis J; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra, Gothenburg, Sweden., Chen CY; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lepamets M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Lin K; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Liu S; BGI-Shenzhen, Shenzhen, 518083, Guangdong, China.; Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200, Copenhagen, Denmark., Millwood IY; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit (PHRU), University of Oxford, Oxford, UK., Ramu A; Department of Genetics, Washington University in St. Louis, Saint Louis, MO, USA., Southcombe J; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Andersen MS; Department of Endocrinology, Odense University Hospital, Odense, Denmark., Yang L; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit (PHRU), University of Oxford, Oxford, UK., Becker CM; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Børglum AD; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.; Center for Genomics and Personalized Medicine, Aarhus University and University Hospital, Aarhus, Denmark., Gordon SD; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Bybjerg-Grauholm J; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Helgeland Ø; Department of Genetics and Bioinformatics, Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway.; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020, Bergen, Norway., Hougaard DM; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Jin X; BGI-Shenzhen, Shenzhen, 518083, Guangdong, China.; School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong, China., Johansson S; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020, Bergen, Norway.; Department of Medical Genetics, Haukeland University Hospital, N-5021, Bergen, Norway., Juodakis J; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Kartsonaki C; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit (PHRU), University of Oxford, Oxford, UK., Kukushkina V; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Lind PA; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Montgomery GW; University of Queensland, St Lucia, QLD, Australia., Morris AP; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Mors O; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark., Mortensen PB; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Njølstad PR; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020, Bergen, Norway.; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway., Nordentoft M; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Copenhagen University Hospital, Mental Health Center Copenhagen, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark., Nyholt DR; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia., Lippincott M; Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Seminara S; Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Salumets A; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.; Competence Centre on Health Technologies, Tartu, Estonia.; Institute of Bio- and Translational Medicine, University of Tartu, Tartu, Estonia.; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zondervan K; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Werge T; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Chen Z; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Conrad DF; Department of Genetics, Washington University in St. Louis, Saint Louis, MO, USA., Jacobsson B; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra, Gothenburg, Sweden.; Department of Genetics and Bioinformatics, Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway., Li L; Department of Epidemiology & Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China., Martin NG; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Neale BM; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nielsen R; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Walters RG; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit (PHRU), University of Oxford, Oxford, UK., Granne I; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Medland SE; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Lawlor DA; MRC Integrated Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Bristol National Institute of Health Research Biomedical Research Centre, Bristol, UK., Lindgren CM; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK. cecilia.lindgren@bdi.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. cecilia.lindgren@bdi.ox.ac.uk.; Program in Medical and Population Genetics, Broad Institute, Boston, MA, USA. cecilia.lindgren@bdi.ox.ac.uk.
Source: Nature communications [Nat Commun] 2020 Nov 25; Vol. 11 (1), pp. 5980. Date of Electronic Publication: 2020 Nov 25.
Publication Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-020-19742-5