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Pan-cancer population pharmacokinetics and exposure-safety and -efficacy analyses of atezolizumab in patients with high tumor mutational burden.

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Title: Pan-cancer population pharmacokinetics and exposure-safety and -efficacy analyses of atezolizumab in patients with high tumor mutational burden.
Authors: Shemesh CS; Clinical Pharmacology, Genentech Inc., South San Francisco, CA, USA., Chan P; Clinical Pharmacology, Genentech Inc., South San Francisco, CA, USA., Legrand FA; Clinical Science, Genentech Inc., South San Francisco, CA, USA., Shames DS; Biomarkers, Genentech Inc., South San Francisco, CA, USA., Das Thakur M; Biomarkers, Genentech Inc., South San Francisco, CA, USA., Shi J; Safety Science, F. Hoffmann-La Roche Ltd., Shanghai, China., Bailey L; Safety Science, Roche Products Ltd., Welwyn Garden City, United Kingdom., Vadhavkar S; Clinical Pharmacology, Genentech Inc., South San Francisco, CA, USA., He X; Biometrics, Genentech Inc., South San Francisco, CA, USA., Zhang W; Biometrics, Genentech Inc., South San Francisco, CA, USA., Bruno R; Clinical Pharmacology, Genentech-Roche, Marseille, France.
Source: Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Dec; Vol. 8 (6), pp. e00685.
Publication Type: Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 101626369 Publication Model: Print Cited Medium: Internet ISSN: 2052-1707 (Electronic) Linking ISSN: 20521707 NLM ISO Abbreviation: Pharmacol Res Perspect Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pan-cancer population pharmacokinetics and exposure-safety and -efficacy analyses of atezolizumab in patients with high tumor mutational burden.
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  Data: <searchLink fieldCode="AU" term="%22Shemesh+CS%22">Shemesh CS</searchLink>; Clinical Pharmacology, Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chan+P%22">Chan P</searchLink>; Clinical Pharmacology, Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Legrand+FA%22">Legrand FA</searchLink>; Clinical Science, Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shames+DS%22">Shames DS</searchLink>; Biomarkers, Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Das+Thakur+M%22">Das Thakur M</searchLink>; Biomarkers, Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; Safety Science, F. Hoffmann-La Roche Ltd., Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Bailey+L%22">Bailey L</searchLink>; Safety Science, Roche Products Ltd., Welwyn Garden City, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vadhavkar+S%22">Vadhavkar S</searchLink>; Clinical Pharmacology, Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Biometrics, Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Biometrics, Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bruno+R%22">Bruno R</searchLink>; Clinical Pharmacology, Genentech-Roche, Marseille, France.
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  Data: Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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              Text: 2020 Dec
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