Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia.
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| Title: | Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia. |
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| Authors: | Meier ER; Indiana Hemophilia and Thrombosis Center, Indianapolis, IN, USA., Creary SE; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH, USA.; Center for Innovation in Pediatric Practice, Nationwide Children's Hospital Research Institute, The Ohio State University, Columbus, OH, USA., Heeney MM; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Dong M; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Appiah-Kubi AO; Pediatric Hematology, Children's Hospitals and Clinics of Minnesota, Minneapolis and St. Paul, MN, USA., Nelson SC; Division of Hematology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH, 45229, USA., Niss O; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Piccone C; Case Western Reserve University School of Medicine, Department of Hematology and Oncology, University Hospitals Rainbow Babies and Children's, Cleveland, OH, USA., Quarmyne MO; Emory University School of Medicine & Sickle Cell Disease Program, Children's Healthcare of Atlanta, Atlanta, GA, USA., Quinn CT; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Saving KL; University of Illinois Peioria, Peoria, IL, USA., Scott JP; Medical College of Wisconsin, Milwaukee, WI, USA., Talati R; Cleveland Clinic, Cleveland, OH, USA., Latham TS; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Pfeiffer A; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Shook LM; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Vinks AA; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Lane A; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., McGann PT; University of Cincinnati College of Medicine, Cincinnati, OH, USA. patrick.mcgann@cchmc.org.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA. patrick.mcgann@cchmc.org. |
| Source: | Trials [Trials] 2020 Nov 27; Vol. 21 (1), pp. 983. Date of Electronic Publication: 2020 Nov 27. |
| Publication Type: | Clinical Trial Protocol; Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1745-6215 |
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| DOI: | 10.1186/s13063-020-04912-z |
