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Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia.

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Title: Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia.
Authors: Meier ER; Indiana Hemophilia and Thrombosis Center, Indianapolis, IN, USA., Creary SE; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH, USA.; Center for Innovation in Pediatric Practice, Nationwide Children's Hospital Research Institute, The Ohio State University, Columbus, OH, USA., Heeney MM; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Dong M; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Appiah-Kubi AO; Pediatric Hematology, Children's Hospitals and Clinics of Minnesota, Minneapolis and St. Paul, MN, USA., Nelson SC; Division of Hematology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH, 45229, USA., Niss O; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Piccone C; Case Western Reserve University School of Medicine, Department of Hematology and Oncology, University Hospitals Rainbow Babies and Children's, Cleveland, OH, USA., Quarmyne MO; Emory University School of Medicine & Sickle Cell Disease Program, Children's Healthcare of Atlanta, Atlanta, GA, USA., Quinn CT; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Saving KL; University of Illinois Peioria, Peoria, IL, USA., Scott JP; Medical College of Wisconsin, Milwaukee, WI, USA., Talati R; Cleveland Clinic, Cleveland, OH, USA., Latham TS; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Pfeiffer A; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Shook LM; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Vinks AA; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Lane A; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., McGann PT; University of Cincinnati College of Medicine, Cincinnati, OH, USA. patrick.mcgann@cchmc.org.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA. patrick.mcgann@cchmc.org.
Source: Trials [Trials] 2020 Nov 27; Vol. 21 (1), pp. 983. Date of Electronic Publication: 2020 Nov 27.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia.
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  Data: <searchLink fieldCode="AU" term="%22Meier+ER%22">Meier ER</searchLink>; Indiana Hemophilia and Thrombosis Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Creary+SE%22">Creary SE</searchLink>; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH, USA.; Center for Innovation in Pediatric Practice, Nationwide Children's Hospital Research Institute, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Heeney+MM%22">Heeney MM</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dong+M%22">Dong M</searchLink>; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Appiah-Kubi+AO%22">Appiah-Kubi AO</searchLink>; Pediatric Hematology, Children's Hospitals and Clinics of Minnesota, Minneapolis and St. Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+SC%22">Nelson SC</searchLink>; Division of Hematology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH, 45229, USA.<br /><searchLink fieldCode="AU" term="%22Niss+O%22">Niss O</searchLink>; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.<br /><searchLink fieldCode="AU" term="%22Piccone+C%22">Piccone C</searchLink>; Case Western Reserve University School of Medicine, Department of Hematology and Oncology, University Hospitals Rainbow Babies and Children's, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Quarmyne+MO%22">Quarmyne MO</searchLink>; Emory University School of Medicine & Sickle Cell Disease Program, Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Quinn+CT%22">Quinn CT</searchLink>; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.<br /><searchLink fieldCode="AU" term="%22Saving+KL%22">Saving KL</searchLink>; University of Illinois Peioria, Peoria, IL, USA.<br /><searchLink fieldCode="AU" term="%22Scott+JP%22">Scott JP</searchLink>; Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Talati+R%22">Talati R</searchLink>; Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Latham+TS%22">Latham TS</searchLink>; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pfeiffer+A%22">Pfeiffer A</searchLink>; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shook+LM%22">Shook LM</searchLink>; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vinks+AA%22">Vinks AA</searchLink>; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lane+A%22">Lane A</searchLink>; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.<br /><searchLink fieldCode="AU" term="%22McGann+PT%22">McGann PT</searchLink>; University of Cincinnati College of Medicine, Cincinnati, OH, USA. patrick.mcgann@cchmc.org.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA. patrick.mcgann@cchmc.org.
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  Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2020 Nov 27; Vol. 21 (1), pp. 983. <i>Date of Electronic Publication: </i>2020 Nov 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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