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Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.

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Title: Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.
Authors: Leimkühler NB; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands., Gleitz HFE; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands., Ronghui L; Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen 52074 Germany., Snoeren IAM; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands., Fuchs SNR; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands., Nagai JS; Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen 52074 Germany., Banjanin B; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands., Lam KH; Department of Pathology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands., Vogl T; Institute of Immunology, University of Münster, Münster 49148, Germany., Kuppe C; Division of Nephrology and Clinical Immunology, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany., Stalmann USA; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands., Büsche G; Institute of Pathology, Hannover Medical School, Hannover 30625, Germany., Kreipe H; Institute of Pathology, Hannover Medical School, Hannover 30625, Germany., Gütgemann I; Institute of Pathology, University of Bonn, Bonn 53127, Germany., Krebs P; Institute of Pathology, University of Bern, Bern 3012, Switzerland., Banz Y; Institute of Pathology, University of Bern, Bern 3012, Switzerland., Boor P; Institute of Pathology, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany., Tai EW; Institute of Pathology, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany., Brümmendorf TH; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany., Koschmieder S; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany., Crysandt M; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany., Bindels E; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands., Kramann R; Division of Nephrology and Clinical Immunology, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen 52074, Germany., Costa IG; Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen 52074 Germany., Schneider RK; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands; Department of Cell Biology, Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands. Electronic address: reschneider@ukaachen.de.
Source: Cell stem cell [Cell Stem Cell] 2021 Apr 01; Vol. 28 (4), pp. 637-652.e8. Date of Electronic Publication: 2020 Dec 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE
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  Data: Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.
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  Data: <searchLink fieldCode="AU" term="%22Leimkühler+NB%22">Leimkühler NB</searchLink>; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gleitz+HFE%22">Gleitz HFE</searchLink>; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ronghui+L%22">Ronghui L</searchLink>; Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen 52074 Germany.<br /><searchLink fieldCode="AU" term="%22Snoeren+IAM%22">Snoeren IAM</searchLink>; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fuchs+SNR%22">Fuchs SNR</searchLink>; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nagai+JS%22">Nagai JS</searchLink>; Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen 52074 Germany.<br /><searchLink fieldCode="AU" term="%22Banjanin+B%22">Banjanin B</searchLink>; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lam+KH%22">Lam KH</searchLink>; Department of Pathology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vogl+T%22">Vogl T</searchLink>; Institute of Immunology, University of Münster, Münster 49148, Germany.<br /><searchLink fieldCode="AU" term="%22Kuppe+C%22">Kuppe C</searchLink>; Division of Nephrology and Clinical Immunology, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany.<br /><searchLink fieldCode="AU" term="%22Stalmann+USA%22">Stalmann USA</searchLink>; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Büsche+G%22">Büsche G</searchLink>; Institute of Pathology, Hannover Medical School, Hannover 30625, Germany.<br /><searchLink fieldCode="AU" term="%22Kreipe+H%22">Kreipe H</searchLink>; Institute of Pathology, Hannover Medical School, Hannover 30625, Germany.<br /><searchLink fieldCode="AU" term="%22Gütgemann+I%22">Gütgemann I</searchLink>; Institute of Pathology, University of Bonn, Bonn 53127, Germany.<br /><searchLink fieldCode="AU" term="%22Krebs+P%22">Krebs P</searchLink>; Institute of Pathology, University of Bern, Bern 3012, Switzerland.<br /><searchLink fieldCode="AU" term="%22Banz+Y%22">Banz Y</searchLink>; Institute of Pathology, University of Bern, Bern 3012, Switzerland.<br /><searchLink fieldCode="AU" term="%22Boor+P%22">Boor P</searchLink>; Institute of Pathology, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany.<br /><searchLink fieldCode="AU" term="%22Tai+EW%22">Tai EW</searchLink>; Institute of Pathology, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany.<br /><searchLink fieldCode="AU" term="%22Brümmendorf+TH%22">Brümmendorf TH</searchLink>; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany.<br /><searchLink fieldCode="AU" term="%22Koschmieder+S%22">Koschmieder S</searchLink>; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany.<br /><searchLink fieldCode="AU" term="%22Crysandt+M%22">Crysandt M</searchLink>; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany.<br /><searchLink fieldCode="AU" term="%22Bindels+E%22">Bindels E</searchLink>; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kramann+R%22">Kramann R</searchLink>; Division of Nephrology and Clinical Immunology, Faculty of Medicine, RWTH Aachen University, Aachen 52074, Germany; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen 52074, Germany.<br /><searchLink fieldCode="AU" term="%22Costa+IG%22">Costa IG</searchLink>; Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen 52074 Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+RK%22">Schneider RK</searchLink>; Department of Hematology, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands; Department of Cell Biology, Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands. Electronic address: reschneider@ukaachen.de.
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  Data: <searchLink fieldCode="JN" term="%22101311472%22">Cell stem cell</searchLink> [Cell Stem Cell] 2021 Apr 01; Vol. 28 (4), pp. 637-652.e8. <i>Date of Electronic Publication: </i>2020 Dec 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101311472 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1875-9777 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218759777%22">18759777 </searchLink><i>NLM ISO Abbreviation: </i>Cell Stem Cell <i>Subsets: </i>MEDLINE
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