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Mining Natural Products for Macrocycles to Drug Difficult Targets.

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Title: Mining Natural Products for Macrocycles to Drug Difficult Targets.
Authors: Begnini F; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden., Poongavanam V; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden., Over B; Department of Medicinal Chemistry, Research and Early Development, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden., Castaldo M; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden., Geschwindner S; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden., Johansson P; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden., Tyagi M; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden., Tyrchan C; Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden., Wissler L; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden., Sjö P; Drugs for Neglected Diseases initiative (DNDi), 15 Chemin Louis Dunant, 1202 Geneva, Switzerland., Schiesser S; Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden., Kihlberg J; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.
Source: Journal of medicinal chemistry [J Med Chem] 2021 Jan 28; Vol. 64 (2), pp. 1054-1072. Date of Electronic Publication: 2020 Dec 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mining Natural Products for Macrocycles to Drug Difficult Targets.
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  Data: <searchLink fieldCode="AU" term="%22Begnini+F%22">Begnini F</searchLink>; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Poongavanam+V%22">Poongavanam V</searchLink>; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Over+B%22">Over B</searchLink>; Department of Medicinal Chemistry, Research and Early Development, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Castaldo+M%22">Castaldo M</searchLink>; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Geschwindner+S%22">Geschwindner S</searchLink>; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Johansson+P%22">Johansson P</searchLink>; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Tyagi+M%22">Tyagi M</searchLink>; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Tyrchan+C%22">Tyrchan C</searchLink>; Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Wissler+L%22">Wissler L</searchLink>; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Sjö+P%22">Sjö P</searchLink>; Drugs for Neglected Diseases initiative (DNDi), 15 Chemin Louis Dunant, 1202 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schiesser+S%22">Schiesser S</searchLink>; Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Kihlberg+J%22">Kihlberg J</searchLink>; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2021 Jan 28; Vol. 64 (2), pp. 1054-1072. <i>Date of Electronic Publication: </i>2020 Dec 18.
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              Text: 2021 Jan 28
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