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Mining Natural Products for Macrocycles to Drug Difficult Targets.

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Bibliographic Details
Title: Mining Natural Products for Macrocycles to Drug Difficult Targets.
Authors: Begnini F; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden., Poongavanam V; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden., Over B; Department of Medicinal Chemistry, Research and Early Development, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden., Castaldo M; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden., Geschwindner S; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden., Johansson P; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden., Tyagi M; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden., Tyrchan C; Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden., Wissler L; Structure, Biophysics & Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, 43183 Mölndal, Sweden., Sjö P; Drugs for Neglected Diseases initiative (DNDi), 15 Chemin Louis Dunant, 1202 Geneva, Switzerland., Schiesser S; Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden., Kihlberg J; Department of Chemistry - BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.
Source: Journal of medicinal chemistry [J Med Chem] 2021 Jan 28; Vol. 64 (2), pp. 1054-1072. Date of Electronic Publication: 2020 Dec 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.0c01569