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Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial.

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Title: Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial.
Authors: Weiss MD; Department of Neurology, University of Washington, Seattle, Washington, USA., Macklin EA; Department of Medicine, Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., McIlduff CE; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Vucic S; Department of Neurology, Royal Prince Alfred Hospital; and the Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Wainger BJ; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA., Kiernan MC; Department of Neurology, Royal Prince Alfred Hospital; and the Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Goutman SA; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Goyal NA; Department of Neurology, University of California, Irvine, California, USA., Rutkove SB; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Ladha SS; Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA., Chen IA; Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA., Harms MB; Department of Neurology, Columbia University, New York, New York, USA., Brannagan TH; Department of Neurology, Columbia University, New York, New York, USA., Lacomis D; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Zivkovic S; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Ma M; Department of Neurology, University of Washington, Seattle, Washington, USA., Wang LH; Department of Neurology, University of Washington, Seattle, Washington, USA., Simmons Z; Department of Neurology, Penn State University, Hershey, Pennsylvania, USA., Rivner MH; Department of Neurology, Augusta University, Augusta, Georgia, USA., Shefner JM; Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA., Cudkowicz ME; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA., Atassi N; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Corporate Authors: Mexiletine-2 ALS Study Group
Source: Muscle & nerve [Muscle Nerve] 2021 Mar; Vol. 63 (3), pp. 371-383. Date of Electronic Publication: 2020 Dec 31.
Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 7803146 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4598 (Electronic) Linking ISSN: 0148639X NLM ISO Abbreviation: Muscle Nerve Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Weiss+MD%22">Weiss MD</searchLink>; Department of Neurology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Macklin+EA%22">Macklin EA</searchLink>; Department of Medicine, Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22McIlduff+CE%22">McIlduff CE</searchLink>; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Vucic+S%22">Vucic S</searchLink>; Department of Neurology, Royal Prince Alfred Hospital; and the Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Wainger+BJ%22">Wainger BJ</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kiernan+MC%22">Kiernan MC</searchLink>; Department of Neurology, Royal Prince Alfred Hospital; and the Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Goutman+SA%22">Goutman SA</searchLink>; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Goyal+NA%22">Goyal NA</searchLink>; Department of Neurology, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Rutkove+SB%22">Rutkove SB</searchLink>; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ladha+SS%22">Ladha SS</searchLink>; Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Chen+IA%22">Chen IA</searchLink>; Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Harms+MB%22">Harms MB</searchLink>; Department of Neurology, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Brannagan+TH%22">Brannagan TH</searchLink>; Department of Neurology, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lacomis+D%22">Lacomis D</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Zivkovic+S%22">Zivkovic S</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Ma+M%22">Ma M</searchLink>; Department of Neurology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Wang+LH%22">Wang LH</searchLink>; Department of Neurology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Simmons+Z%22">Simmons Z</searchLink>; Department of Neurology, Penn State University, Hershey, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Rivner+MH%22">Rivner MH</searchLink>; Department of Neurology, Augusta University, Augusta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Shefner+JM%22">Shefner JM</searchLink>; Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Cudkowicz+ME%22">Cudkowicz ME</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Atassi+N%22">Atassi N</searchLink>; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
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  Data: <searchLink fieldCode="CA" term="%22Mexiletine-2+ALS+Study+Group%22">Mexiletine-2 ALS Study Group</searchLink>
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  Data: <searchLink fieldCode="JN" term="%227803146%22">Muscle & nerve</searchLink> [Muscle Nerve] 2021 Mar; Vol. 63 (3), pp. 371-383. <i>Date of Electronic Publication: </i>2020 Dec 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%22">John Wiley & Sons </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7803146 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4598 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220148639X%22">0148639X </searchLink><i>NLM ISO Abbreviation: </i>Muscle Nerve <i>Subsets: </i>MEDLINE
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