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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.

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Title: Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.
Authors: Tothova Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Valton AL; Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Gorelov RA; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Vallurupalli M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Krill-Burger JM; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Holmes A; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Landers CC; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Haydu JE; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Malolepsza E; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Hartigan C; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Donahue M; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Popova KD; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Koochaki S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Venev SV; Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Rivera J; Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Chen E; Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Lage K; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Schenone M; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., D'Andrea AD; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Carr SA; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA., Morgan EA; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Dekker J; Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
Source: JCI insight [JCI Insight] 2021 Feb 08; Vol. 6 (3). Date of Electronic Publication: 2021 Feb 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.
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  Data: <searchLink fieldCode="AU" term="%22Tothova+Z%22">Tothova Z</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Valton+AL%22">Valton AL</searchLink>; Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gorelov+RA%22">Gorelov RA</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Vallurupalli+M%22">Vallurupalli M</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Krill-Burger+JM%22">Krill-Burger JM</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Holmes+A%22">Holmes A</searchLink>; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Landers+CC%22">Landers CC</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Haydu+JE%22">Haydu JE</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Malolepsza+E%22">Malolepsza E</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hartigan+C%22">Hartigan C</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Donahue+M%22">Donahue M</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Popova+KD%22">Popova KD</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Koochaki+S%22">Koochaki S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Venev+SV%22">Venev SV</searchLink>; Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Rivera+J%22">Rivera J</searchLink>; Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chen+E%22">Chen E</searchLink>; Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lage+K%22">Lage K</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Schenone+M%22">Schenone M</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22D'Andrea+AD%22">D'Andrea AD</searchLink>; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Carr+SA%22">Carr SA</searchLink>; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+EA%22">Morgan EA</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Dekker+J%22">Dekker J</searchLink>; Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ebert+BL%22">Ebert BL</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2021 Feb 08; Vol. 6 (3). <i>Date of Electronic Publication: </i>2021 Feb 08.
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