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Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma.

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Title: Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma.
Authors: Mayr L; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria., Guntner AS; Institute of Analytical Chemistry, Johannes Kepler University, 4020 Linz, Austria., Madlener S; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria., Schmook MT; Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria., Peyrl A; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria., Azizi AA; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria., Dieckmann K; Department of Radiotherapy, Medical University of Vienna, 1090 Vienna, Austria., Reisinger D; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria., Stepien NM; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria., Schramm K; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Laemmerer A; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Ecker J; Clinical Cooperation Unit Pediatric Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany., Sahm F; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Milde T; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany., Pajtler KW; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Blattner-Johnson M; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Strbac M; Department of Laboratory Medicine and Pathology, Tree Top Hospital, Hulhumale 23000, Maldives., Dorfer C; Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria., Czech T; Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria., Kirchhofer D; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria., Gabler L; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria., Berger W; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria., Haberler C; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria., Müllauer L; Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria., Buchberger W; Institute of Analytical Chemistry, Johannes Kepler University, 4020 Linz, Austria., Slavc I; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria., Lötsch-Gojo D; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.; Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria., Gojo J; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Source: Journal of personalized medicine [J Pers Med] 2020 Dec 18; Vol. 10 (4). Date of Electronic Publication: 2020 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
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  Data: Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma.
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  Data: <searchLink fieldCode="AU" term="%22Mayr+L%22">Mayr L</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Guntner+AS%22">Guntner AS</searchLink>; Institute of Analytical Chemistry, Johannes Kepler University, 4020 Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Madlener+S%22">Madlener S</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schmook+MT%22">Schmook MT</searchLink>; Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Peyrl+A%22">Peyrl A</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Azizi+AA%22">Azizi AA</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Dieckmann+K%22">Dieckmann K</searchLink>; Department of Radiotherapy, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Reisinger+D%22">Reisinger D</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Stepien+NM%22">Stepien NM</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schramm+K%22">Schramm K</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Laemmerer+A%22">Laemmerer A</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Jones+DTW%22">Jones DTW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ecker+J%22">Ecker J</searchLink>; Clinical Cooperation Unit Pediatric Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sahm+F%22">Sahm F</searchLink>; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Milde+T%22">Milde T</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pajtler+KW%22">Pajtler KW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Blattner-Johnson+M%22">Blattner-Johnson M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Strbac+M%22">Strbac M</searchLink>; Department of Laboratory Medicine and Pathology, Tree Top Hospital, Hulhumale 23000, Maldives.<br /><searchLink fieldCode="AU" term="%22Dorfer+C%22">Dorfer C</searchLink>; Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Czech+T%22">Czech T</searchLink>; Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kirchhofer+D%22">Kirchhofer D</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gabler+L%22">Gabler L</searchLink>; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Berger+W%22">Berger W</searchLink>; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Haberler+C%22">Haberler C</searchLink>; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Müllauer+L%22">Müllauer L</searchLink>; Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Buchberger+W%22">Buchberger W</searchLink>; Institute of Analytical Chemistry, Johannes Kepler University, 4020 Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Slavc+I%22">Slavc I</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lötsch-Gojo+D%22">Lötsch-Gojo D</searchLink>; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.; Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gojo+J%22">Gojo J</searchLink>; Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.; Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
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