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LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors.

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Title: LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors.
Authors: Monaco KA; Bristol Myers-Squibb, Cambridge, Massachusetts., Delach S; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Yuan J; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Mishina Y; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Fordjour P; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Labrot E; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., McKay D; Ventus Therapeutics, Montreal, Quebec, Canada., Guo R; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Higgins S; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Wang HQ; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Liang J; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Bui K; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Green J; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Aspesi P; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Ambrose J; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Mapa F; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Griner L; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Jaskelioff M; Skyhawk Therapeutics, Waltham, Massachusetts., Fuller J; Novartis Institutes for Biomedical Research, Emeryville, California., Crawford K; AbSci, Vancouver, Washington., Pardee G; Novartis Institutes for Biomedical Research, Emeryville, California., Widger S; Novartis Institutes for Biomedical Research, Emeryville, California., Hammerman PS; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Engelman JA; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Stuart DD; Scorpion Therapeutics, Boston, Massachusetts., Cooke VG; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Caponigro G; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts. giordano.caponigro@novartis.com.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Apr 01; Vol. 27 (7), pp. 2061-2073. Date of Electronic Publication: 2020 Dec 22.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors.
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  Data: <searchLink fieldCode="AU" term="%22Monaco+KA%22">Monaco KA</searchLink>; Bristol Myers-Squibb, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Delach+S%22">Delach S</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Yuan+J%22">Yuan J</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mishina+Y%22">Mishina Y</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Fordjour+P%22">Fordjour P</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Labrot+E%22">Labrot E</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22McKay+D%22">McKay D</searchLink>; Ventus Therapeutics, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Guo+R%22">Guo R</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Higgins+S%22">Higgins S</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Wang+HQ%22">Wang HQ</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Liang+J%22">Liang J</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Bui+K%22">Bui K</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Green+J%22">Green J</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Aspesi+P%22">Aspesi P</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Ambrose+J%22">Ambrose J</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mapa+F%22">Mapa F</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Griner+L%22">Griner L</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Jaskelioff+M%22">Jaskelioff M</searchLink>; Skyhawk Therapeutics, Waltham, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Fuller+J%22">Fuller J</searchLink>; Novartis Institutes for Biomedical Research, Emeryville, California.<br /><searchLink fieldCode="AU" term="%22Crawford+K%22">Crawford K</searchLink>; AbSci, Vancouver, Washington.<br /><searchLink fieldCode="AU" term="%22Pardee+G%22">Pardee G</searchLink>; Novartis Institutes for Biomedical Research, Emeryville, California.<br /><searchLink fieldCode="AU" term="%22Widger+S%22">Widger S</searchLink>; Novartis Institutes for Biomedical Research, Emeryville, California.<br /><searchLink fieldCode="AU" term="%22Hammerman+PS%22">Hammerman PS</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Engelman+JA%22">Engelman JA</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Stuart+DD%22">Stuart DD</searchLink>; Scorpion Therapeutics, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Cooke+VG%22">Cooke VG</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Caponigro+G%22">Caponigro G</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts. giordano.caponigro@novartis.com.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2021 Apr 01; Vol. 27 (7), pp. 2061-2073. <i>Date of Electronic Publication: </i>2020 Dec 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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              Text: 2021 Apr 01
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