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The nucleotide prodrug CERC-913 improves mtDNA content in primary hepatocytes from DGUOK-deficient rats.

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Title: The nucleotide prodrug CERC-913 improves mtDNA content in primary hepatocytes from DGUOK-deficient rats.
Authors: Vanden Avond MA; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Meng H; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Beatka MJ; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Helbling DC; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Prom MJ; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Sutton JL; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Slick RA; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Dimmock DP; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, California, USA., Pertusati F; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK., Serpi M; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK., Pileggi E; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK., Crutcher P; Discovery R&D, Cerecor Inc., Rockville, Maryland, USA., Thomas S; Discovery R&D, Cerecor Inc., Rockville, Maryland, USA., Lawlor MW; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Source: Journal of inherited metabolic disease [J Inherit Metab Dis] 2021 Mar; Vol. 44 (2), pp. 492-501. Date of Electronic Publication: 2021 Jan 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 7910918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2665 (Electronic) Linking ISSN: 01418955 NLM ISO Abbreviation: J Inherit Metab Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The nucleotide prodrug CERC-913 improves mtDNA content in primary hepatocytes from DGUOK-deficient rats.
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  Data: <searchLink fieldCode="AU" term="%22Vanden+Avond+MA%22">Vanden Avond MA</searchLink>; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Meng+H%22">Meng H</searchLink>; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Beatka+MJ%22">Beatka MJ</searchLink>; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Helbling+DC%22">Helbling DC</searchLink>; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Prom+MJ%22">Prom MJ</searchLink>; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Sutton+JL%22">Sutton JL</searchLink>; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Slick+RA%22">Slick RA</searchLink>; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Dimmock+DP%22">Dimmock DP</searchLink>; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Pertusati+F%22">Pertusati F</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Serpi+M%22">Serpi M</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Pileggi+E%22">Pileggi E</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Crutcher+P%22">Crutcher P</searchLink>; Discovery R&D, Cerecor Inc., Rockville, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+S%22">Thomas S</searchLink>; Discovery R&D, Cerecor Inc., Rockville, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lawlor+MW%22">Lawlor MW</searchLink>; Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
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  Data: <searchLink fieldCode="JN" term="%227910918%22">Journal of inherited metabolic disease</searchLink> [J Inherit Metab Dis] 2021 Mar; Vol. 44 (2), pp. 492-501. <i>Date of Electronic Publication: </i>2021 Jan 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7910918 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-2665 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201418955%22">01418955 </searchLink><i>NLM ISO Abbreviation: </i>J Inherit Metab Dis <i>Subsets: </i>MEDLINE
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