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Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?

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Title: Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
Authors: Burks SM; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA., Rosas-Hernandez H; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA., Alejandro Ramirez-Lee M; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA., Cuevas E; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA., Talpos JC; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: John.Talpos@fda.hhs.gov.
Source: Brain, behavior, and immunity [Brain Behav Immun] 2021 Jul; Vol. 95, pp. 7-14. Date of Electronic Publication: 2021 Jan 04.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Burks+SM%22">Burks SM</searchLink>; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA.<br /><searchLink fieldCode="AU" term="%22Rosas-Hernandez+H%22">Rosas-Hernandez H</searchLink>; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA.<br /><searchLink fieldCode="AU" term="%22Alejandro+Ramirez-Lee+M%22">Alejandro Ramirez-Lee M</searchLink>; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA.<br /><searchLink fieldCode="AU" term="%22Cuevas+E%22">Cuevas E</searchLink>; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA.<br /><searchLink fieldCode="AU" term="%22Talpos+JC%22">Talpos JC</searchLink>; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: John.Talpos@fda.hhs.gov.
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  Data: <searchLink fieldCode="JN" term="%228800478%22">Brain, behavior, and immunity</searchLink> [Brain Behav Immun] 2021 Jul; Vol. 95, pp. 7-14. <i>Date of Electronic Publication: </i>2021 Jan 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8800478 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2139 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208891591%22">08891591 </searchLink><i>NLM ISO Abbreviation: </i>Brain Behav Immun <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bbi.2020.12.031
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      – Code: eng
        Text: English
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              Text: 2021 Jul
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