Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds.
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| Title: | Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds. |
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| Authors: | Kolarič A; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia., Germe T; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK., Hrast M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia., Stevenson CEM; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK., Lawson DM; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK., Burton NP; Inspiralis Ltd., Innovation Centre, Norwich Research Park, Colney Lane, Norwich, NR4 7GJ, UK., Vörös J; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK., Maxwell A; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK., Minovski N; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia. nikola.minovski@ki.si., Anderluh M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia. marko.anderluh@ffa.uni-lj.si. |
| Source: | Nature communications [Nat Commun] 2021 Jan 08; Vol. 12 (1), pp. 150. Date of Electronic Publication: 2021 Jan 08. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-020-20405-8 |
