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Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.

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Title: Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
Authors: Mendes V; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. vgm23@cam.ac.uk., Green SR; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK., Evans JC; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa., Hess J; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Blaszczyk M; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Spry C; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Bryant O; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Cory-Wright J; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Chan DS; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Torres PHM; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Wang Z; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA., Nahiyaan N; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA., O'Neill S; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK., Damerow S; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK., Post J; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK., Bayliss T; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK., Lynch SL; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa., Coyne AG; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Ray PC; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK., Abell C; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Rhee KY; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA., Boshoff HIM; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA., Barry CE 3rd; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA., Mizrahi V; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa., Wyatt PG; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK., Blundell TL; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. tom@cryst.bioc.cam.ac.uk.
Source: Nature communications [Nat Commun] 2021 Jan 08; Vol. 12 (1), pp. 143. Date of Electronic Publication: 2021 Jan 08.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
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  Data: <searchLink fieldCode="AU" term="%22Mendes+V%22">Mendes V</searchLink>; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. vgm23@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Green+SR%22">Green SR</searchLink>; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Evans+JC%22">Evans JC</searchLink>; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Hess+J%22">Hess J</searchLink>; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.<br /><searchLink fieldCode="AU" term="%22Blaszczyk+M%22">Blaszczyk M</searchLink>; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.<br /><searchLink fieldCode="AU" term="%22Spry+C%22">Spry C</searchLink>; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.<br /><searchLink fieldCode="AU" term="%22Bryant+O%22">Bryant O</searchLink>; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.<br /><searchLink fieldCode="AU" term="%22Cory-Wright+J%22">Cory-Wright J</searchLink>; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.<br /><searchLink fieldCode="AU" term="%22Chan+DS%22">Chan DS</searchLink>; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.<br /><searchLink fieldCode="AU" term="%22Torres+PHM%22">Torres PHM</searchLink>; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Nahiyaan+N%22">Nahiyaan N</searchLink>; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22O'Neill+S%22">O'Neill S</searchLink>; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Damerow+S%22">Damerow S</searchLink>; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Post+J%22">Post J</searchLink>; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Bayliss+T%22">Bayliss T</searchLink>; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Lynch+SL%22">Lynch SL</searchLink>; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Coyne+AG%22">Coyne AG</searchLink>; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.<br /><searchLink fieldCode="AU" term="%22Ray+PC%22">Ray PC</searchLink>; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Abell+C%22">Abell C</searchLink>; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.<br /><searchLink fieldCode="AU" term="%22Rhee+KY%22">Rhee KY</searchLink>; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Boshoff+HIM%22">Boshoff HIM</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Barry+CE+3rd%22">Barry CE 3rd</searchLink>; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Mizrahi+V%22">Mizrahi V</searchLink>; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Wyatt+PG%22">Wyatt PG</searchLink>; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Blundell+TL%22">Blundell TL</searchLink>; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. tom@cryst.bioc.cam.ac.uk.
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