Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial.

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Title: Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial.
Authors: Westhovens R; Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Flanders, Belgium rene.westhovens@uzleuven.be.; Division of Rheumatology, University Hospitals KU Leuven, Leuven, Flanders, Belgium., Rigby WFC; Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA., van der Heijde D; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Ching DWT; Timaru Medical Specialists Limited, Timaru, New Zealand., Stohl W; University of Southern California Keck School of Medicine, Los Angeles, California, USA., Kay J; Division of Rheumatology, Department of Medicine, UMass Memorial Medical Center, Worcester, Massachusetts, USA.; Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Chopra A; Centre for Rheumatic Diseases, Pune, India., Bartok B; Gilead Sciences, Foster City, California, USA., Matzkies F; Gilead Sciences, Foster City, California, USA., Yin Z; Gilead Sciences, Foster City, California, USA., Guo Y; Gilead Sciences, Foster City, California, USA., Tasset C; Galapagos NV, Mechelen, Belgium., Sundy JS; Gilead Sciences, Foster City, California, USA.; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Jahreis A; Gilead Sciences, Foster City, California, USA., Mozaffarian N; Ichnos Sciences, New York, New York, USA., Messina OD; Cosme Argerich Hospital, Buenos Aires, Argentina.; Investigaciones Reumatologicas y Osteologicas SRL IRO, Buenos Aires, Argentina., Landewé RB; Department of Rheumatology & Clinical Immunology, Amsterdam University Medical Center, Amsterdam, The Netherlands.; Department of Rheumatology, Zuyderland Hospital, Heerlen, The Netherlands., Atsumi T; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan., Burmester GR; Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany.; Free University and Humboldt University, Berlin, Germany.
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2021 Jun; Vol. 80 (6), pp. 727-738. Date of Electronic Publication: 2021 Jan 15.
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Westhovens+R%22">Westhovens R</searchLink>; Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Flanders, Belgium rene.westhovens@uzleuven.be.; Division of Rheumatology, University Hospitals KU Leuven, Leuven, Flanders, Belgium.<br /><searchLink fieldCode="AU" term="%22Rigby+WFC%22">Rigby WFC</searchLink>; Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.<br /><searchLink fieldCode="AU" term="%22van+der+Heijde+D%22">van der Heijde D</searchLink>; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ching+DWT%22">Ching DWT</searchLink>; Timaru Medical Specialists Limited, Timaru, New Zealand.<br /><searchLink fieldCode="AU" term="%22Stohl+W%22">Stohl W</searchLink>; University of Southern California Keck School of Medicine, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Kay+J%22">Kay J</searchLink>; Division of Rheumatology, Department of Medicine, UMass Memorial Medical Center, Worcester, Massachusetts, USA.; Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Chopra+A%22">Chopra A</searchLink>; Centre for Rheumatic Diseases, Pune, India.<br /><searchLink fieldCode="AU" term="%22Bartok+B%22">Bartok B</searchLink>; Gilead Sciences, Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Matzkies+F%22">Matzkies F</searchLink>; Gilead Sciences, Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Yin+Z%22">Yin Z</searchLink>; Gilead Sciences, Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Gilead Sciences, Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Tasset+C%22">Tasset C</searchLink>; Galapagos NV, Mechelen, Belgium.<br /><searchLink fieldCode="AU" term="%22Sundy+JS%22">Sundy JS</searchLink>; Gilead Sciences, Foster City, California, USA.; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Jahreis+A%22">Jahreis A</searchLink>; Gilead Sciences, Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Mozaffarian+N%22">Mozaffarian N</searchLink>; Ichnos Sciences, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Messina+OD%22">Messina OD</searchLink>; Cosme Argerich Hospital, Buenos Aires, Argentina.; Investigaciones Reumatologicas y Osteologicas SRL IRO, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Landewé+RB%22">Landewé RB</searchLink>; Department of Rheumatology & Clinical Immunology, Amsterdam University Medical Center, Amsterdam, The Netherlands.; Department of Rheumatology, Zuyderland Hospital, Heerlen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Atsumi+T%22">Atsumi T</searchLink>; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Burmester+GR%22">Burmester GR</searchLink>; Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany.; Free University and Humboldt University, Berlin, Germany.
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  Data: <searchLink fieldCode="JN" term="%220372355%22">Annals of the rheumatic diseases</searchLink> [Ann Rheum Dis] 2021 Jun; Vol. 80 (6), pp. 727-738. <i>Date of Electronic Publication: </i>2021 Jan 15.
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  Data: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372355 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-2060 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200034967%22">00034967 </searchLink><i>NLM ISO Abbreviation: </i>Ann Rheum Dis <i>Subsets: </i>MEDLINE
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