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Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.

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Title: Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.
Authors: Pandiani C; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Strub T; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Nottet N; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Cheli Y; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Gambi G; Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France., Bille K; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Husser C; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Dalmasso M; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Béranger G; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Lassalle S; Université Côte d'Azur, Nice, France.; Laboratoire de Pathologie clinique et expérimentale, biobanque BB-0033-00025, and IRCAN team 4, FHU OncoAge, Nice, France., Magnone V; Université Côte d'Azur, Nice, France.; CNRS, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Valbonne, France., Pédeutour F; Université Côte d'Azur, Nice, France.; Laboratoire de Génétique des tumeurs solides and IRCAN, Nice, France., Irondelle M; Université Côte d'Azur, Nice, France.; Inserm, Imagery platform, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Maschi C; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France., Nahon-Estève S; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France., Martel A; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France., Caujolle JP; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France., Hofman P; Université Côte d'Azur, Nice, France.; Laboratoire de Pathologie clinique et expérimentale, biobanque BB-0033-00025, and IRCAN team 4, FHU OncoAge, Nice, France., LeBrigand K; Université Côte d'Azur, Nice, France.; CNRS, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Valbonne, France., Davidson I; Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France., Baillif S; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France., Barbry P; Université Côte d'Azur, Nice, France.; CNRS, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Valbonne, France., Ballotti R; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Bertolotto C; Université Côte d'Azur, Nice, France. corine.bertolotto-ballotti@inserm.fr.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France. corine.bertolotto-ballotti@inserm.fr.
Source: Cell death and differentiation [Cell Death Differ] 2021 Jun; Vol. 28 (6), pp. 1990-2000. Date of Electronic Publication: 2021 Jan 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.
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  Data: <searchLink fieldCode="AU" term="%22Pandiani+C%22">Pandiani C</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Strub+T%22">Strub T</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Nottet+N%22">Nottet N</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Cheli+Y%22">Cheli Y</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Gambi+G%22">Gambi G</searchLink>; Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Bille+K%22">Bille K</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Husser+C%22">Husser C</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Dalmasso+M%22">Dalmasso M</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Béranger+G%22">Béranger G</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Lassalle+S%22">Lassalle S</searchLink>; Université Côte d'Azur, Nice, France.; Laboratoire de Pathologie clinique et expérimentale, biobanque BB-0033-00025, and IRCAN team 4, FHU OncoAge, Nice, France.<br /><searchLink fieldCode="AU" term="%22Magnone+V%22">Magnone V</searchLink>; Université Côte d'Azur, Nice, France.; CNRS, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Pédeutour+F%22">Pédeutour F</searchLink>; Université Côte d'Azur, Nice, France.; Laboratoire de Génétique des tumeurs solides and IRCAN, Nice, France.<br /><searchLink fieldCode="AU" term="%22Irondelle+M%22">Irondelle M</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Imagery platform, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Maschi+C%22">Maschi C</searchLink>; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France.<br /><searchLink fieldCode="AU" term="%22Nahon-Estève+S%22">Nahon-Estève S</searchLink>; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France.<br /><searchLink fieldCode="AU" term="%22Martel+A%22">Martel A</searchLink>; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France.<br /><searchLink fieldCode="AU" term="%22Caujolle+JP%22">Caujolle JP</searchLink>; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France.<br /><searchLink fieldCode="AU" term="%22Hofman+P%22">Hofman P</searchLink>; Université Côte d'Azur, Nice, France.; Laboratoire de Pathologie clinique et expérimentale, biobanque BB-0033-00025, and IRCAN team 4, FHU OncoAge, Nice, France.<br /><searchLink fieldCode="AU" term="%22LeBrigand+K%22">LeBrigand K</searchLink>; Université Côte d'Azur, Nice, France.; CNRS, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Davidson+I%22">Davidson I</searchLink>; Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Baillif+S%22">Baillif S</searchLink>; Université Côte d'Azur, Nice, France.; Pasteur 2 Teaching Hospital, Department of Ophthalmology, Nice, France.<br /><searchLink fieldCode="AU" term="%22Barbry+P%22">Barbry P</searchLink>; Université Côte d'Azur, Nice, France.; CNRS, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Ballotti+R%22">Ballotti R</searchLink>; Université Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Bertolotto+C%22">Bertolotto C</searchLink>; Université Côte d'Azur, Nice, France. corine.bertolotto-ballotti@inserm.fr.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France. corine.bertolotto-ballotti@inserm.fr.
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