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Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial.

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Title: Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial.
Authors: Lopes RD; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.; Brazilian Clinical Research Institute, São Paulo, Brazil.; Rede D'Or São Luiz, São Paulo, Brazil., Macedo AVS; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Hospital São Luiz Jabaquara, São Paulo, Brazil.; Santa Casa de São Paulo, São Paulo, Brazil., de Barros E Silva PGM; Brazilian Clinical Research Institute, São Paulo, Brazil., Moll-Bernardes RJ; D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Dos Santos TM; Brazilian Clinical Research Institute, São Paulo, Brazil.; Insper Institute of Education and Research, São Paulo, Brazil., Mazza L; Brazilian Clinical Research Institute, São Paulo, Brazil., Feldman A; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Hospital São Luiz Anália Franco, São Paulo, Brazil., D'Andréa Saba Arruda G; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Hospital São Luiz São Caetano, São Caetano do Sul, Brazil., de Albuquerque DC; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Camiletti AS; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Rede D'Or São Luiz, São Paulo, Brazil., de Sousa AS; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., de Paula TC; Hospital São Luiz Jabaquara, São Paulo, Brazil., Giusti KGD; Hospital Villa Lobos, São Paulo, Brazil., Domiciano RAM; Hospital São Luiz Anália Franco, São Paulo, Brazil., Noya-Rabelo MM; Hospital São Rafael, Salvador, Brazil.; Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil., Hamilton AM; Hospital São Rafael, Salvador, Brazil., Loures VA; Hospital São Luiz Anália Franco, São Paulo, Brazil., Dionísio RM; Hospital SinoBrasileiro, Osasco, Brazil., Furquim TAB; Hospital SinoBrasileiro, Osasco, Brazil., De Luca FA; Hospital São Luiz Morumbi, São Paulo, Brazil., Dos Santos Sousa ÍB; Hospital São Luiz Morumbi, São Paulo, Brazil., Bandeira BS; Hospital Caxias D'Or, Duque de Caxias, Brazil., Zukowski CN; Hospital Copa D'Or, Rio de Janeiro, Brazil., de Oliveira RGG; Hospital Quinta D'Or, Rio de Janeiro, Brazil., Ribeiro NB; Hospital Santa Luzia, Brasília, Brazil., de Moraes JL; Hospital Assunção, São Bernardo do Campo, Brazil., Petriz JLF; Hospital Barra D'Or, Rio de Janeiro, Brazil., Pimentel AM; Hospital Niterói D'Or, Niterói, Brazil., Miranda JS; Hospital Copa Star, Rio de Janeiro, Brazil., de Jesus Abufaiad BE; Hospital Oeste D'Or, Rio de Janeiro, Brazil., Gibson CM; Harvard Medical School, Harvard University, Boston, Massachusetts., Granger CB; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina., Alexander JH; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina., de Souza OF; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Rede D'Or São Luiz, São Paulo, Brazil.; Hospital Copa Star, Rio de Janeiro, Brazil.
Corporate Authors: BRACE CORONA Investigators
Source: JAMA [JAMA] 2021 Jan 19; Vol. 325 (3), pp. 254-264.
Publication Type: Journal Article; Multicenter Study; Pragmatic Clinical Trial; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
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  Data: Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Lopes+RD%22">Lopes RD</searchLink>; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.; Brazilian Clinical Research Institute, São Paulo, Brazil.; Rede D'Or São Luiz, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Macedo+AVS%22">Macedo AVS</searchLink>; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Hospital São Luiz Jabaquara, São Paulo, Brazil.; Santa Casa de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Barros+E+Silva+PGM%22">de Barros E Silva PGM</searchLink>; Brazilian Clinical Research Institute, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Moll-Bernardes+RJ%22">Moll-Bernardes RJ</searchLink>; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+TM%22">Dos Santos TM</searchLink>; Brazilian Clinical Research Institute, São Paulo, Brazil.; Insper Institute of Education and Research, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Mazza+L%22">Mazza L</searchLink>; Brazilian Clinical Research Institute, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Feldman+A%22">Feldman A</searchLink>; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Hospital São Luiz Anália Franco, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22D'Andréa+Saba+Arruda+G%22">D'Andréa Saba Arruda G</searchLink>; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Hospital São Luiz São Caetano, São Caetano do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Albuquerque+DC%22">de Albuquerque DC</searchLink>; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Camiletti+AS%22">Camiletti AS</searchLink>; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Rede D'Or São Luiz, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+AS%22">de Sousa AS</searchLink>; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Paula+TC%22">de Paula TC</searchLink>; Hospital São Luiz Jabaquara, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Giusti+KGD%22">Giusti KGD</searchLink>; Hospital Villa Lobos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Domiciano+RAM%22">Domiciano RAM</searchLink>; Hospital São Luiz Anália Franco, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Noya-Rabelo+MM%22">Noya-Rabelo MM</searchLink>; Hospital São Rafael, Salvador, Brazil.; Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.<br /><searchLink fieldCode="AU" term="%22Hamilton+AM%22">Hamilton AM</searchLink>; 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Hospital Quinta D'Or, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Ribeiro+NB%22">Ribeiro NB</searchLink>; Hospital Santa Luzia, Brasília, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Moraes+JL%22">de Moraes JL</searchLink>; Hospital Assunção, São Bernardo do Campo, Brazil.<br /><searchLink fieldCode="AU" term="%22Petriz+JLF%22">Petriz JLF</searchLink>; Hospital Barra D'Or, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Pimentel+AM%22">Pimentel AM</searchLink>; Hospital Niterói D'Or, Niterói, Brazil.<br /><searchLink fieldCode="AU" term="%22Miranda+JS%22">Miranda JS</searchLink>; Hospital Copa Star, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Jesus+Abufaiad+BE%22">de Jesus Abufaiad BE</searchLink>; Hospital Oeste D'Or, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Gibson+CM%22">Gibson CM</searchLink>; Harvard Medical School, Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Granger+CB%22">Granger CB</searchLink>; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Alexander+JH%22">Alexander JH</searchLink>; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22de+Souza+OF%22">de Souza OF</searchLink>; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Rede D'Or São Luiz, São Paulo, Brazil.; Hospital Copa Star, Rio de Janeiro, Brazil.
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