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Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.

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Title: Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.
Authors: Ogrodnik M; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Evans SA; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA., Fielder E; Biostatistics Consulting Center, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA., Victorelli S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Kruger P; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Salmonowicz H; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Weigand BM; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Patel AD; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Inman CL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Johnson KO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Dickinson SL; Biostatistics Consulting Center, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA., Rocha A; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA., Schafer MJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Allison DB; Biostatistics Consulting Center, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA., von Zglinicki T; Faculty of Medical Sciences, Biosciences Institute, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Neretti N; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA., Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Kirkland JL; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Jurk D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Source: Aging cell [Aging Cell] 2021 Feb; Vol. 20 (2), pp. e13296. Date of Electronic Publication: 2021 Jan 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
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  Data: Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.
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  Data: <searchLink fieldCode="AU" term="%22Ogrodnik+M%22">Ogrodnik M</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Evans+SA%22">Evans SA</searchLink>; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Fielder+E%22">Fielder E</searchLink>; Biostatistics Consulting Center, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.<br /><searchLink fieldCode="AU" term="%22Victorelli+S%22">Victorelli S</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kruger+P%22">Kruger P</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Salmonowicz+H%22">Salmonowicz H</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Weigand+BM%22">Weigand BM</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Patel+AD%22">Patel AD</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pirtskhalava+T%22">Pirtskhalava T</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Inman+CL%22">Inman CL</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+KO%22">Johnson KO</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Dickinson+SL%22">Dickinson SL</searchLink>; Biostatistics Consulting Center, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.<br /><searchLink fieldCode="AU" term="%22Rocha+A%22">Rocha A</searchLink>; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Schafer+MJ%22">Schafer MJ</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Allison+DB%22">Allison DB</searchLink>; Biostatistics Consulting Center, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.<br /><searchLink fieldCode="AU" term="%22von+Zglinicki+T%22">von Zglinicki T</searchLink>; Faculty of Medical Sciences, Biosciences Institute, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22LeBrasseur+NK%22">LeBrasseur NK</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Tchkonia+T%22">Tchkonia T</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Neretti+N%22">Neretti N</searchLink>; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Passos+JF%22">Passos JF</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kirkland+JL%22">Kirkland JL</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Jurk+D%22">Jurk D</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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