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Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.

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Title: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
Authors: Ku Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Xie X; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA., Davidson E; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA., Ye X; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Su H; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Menachery VD; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA., Li Y; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Yuan Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Zhang X; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA., Muruato AE; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA., I Escuer AG; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA., Tyrell B; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA., Doolan K; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA., Doranz BJ; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA., Wrapp D; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA., Bates PF; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., McLellan JS; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA., Weiss SR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Zhang N; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Ningyan.Zhang@uth.tmc.edu., Shi PY; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA. peshi@UTMB.EDU., An Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Zhiqiang.An@uth.tmc.edu.
Source: Nature communications [Nat Commun] 2021 Jan 20; Vol. 12 (1), pp. 469. Date of Electronic Publication: 2021 Jan 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ku+Z%22">Ku Z</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Xie+X%22">Xie X</searchLink>; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+E%22">Davidson E</searchLink>; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Ye+X%22">Ye X</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Su+H%22">Su H</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Menachery+VD%22">Menachery VD</searchLink>; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+Z%22">Yuan Z</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.<br /><searchLink fieldCode="AU" term="%22Muruato+AE%22">Muruato AE</searchLink>; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.<br /><searchLink fieldCode="AU" term="%22I+Escuer+AG%22">I Escuer AG</searchLink>; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Tyrell+B%22">Tyrell B</searchLink>; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Doolan+K%22">Doolan K</searchLink>; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Doranz+BJ%22">Doranz BJ</searchLink>; Integral Molecular, Philadelphia, Pennsylvania, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wrapp+D%22">Wrapp D</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA.<br /><searchLink fieldCode="AU" term="%22Bates+PF%22">Bates PF</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22McLellan+JS%22">McLellan JS</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+SR%22">Weiss SR</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Ningyan.Zhang@uth.tmc.edu.<br /><searchLink fieldCode="AU" term="%22Shi+PY%22">Shi PY</searchLink>; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA. peshi@UTMB.EDU.<br /><searchLink fieldCode="AU" term="%22An+Z%22">An Z</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Zhiqiang.An@uth.tmc.edu.
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