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Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase.

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Title: Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase.
Authors: Savino AM; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Sheba Medical Center, Ramat Gan, Israel.; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fernandes SI; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Olivares O; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Zemlyansky A; Schneider Children's Medical Center of Israel, Petach Tiqva, Israel., Cousins A; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Markert EK; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Beatson Institute, Glasgow, UK., Barel S; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Sheba Medical Center, Ramat Gan, Israel., Geron I; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Sheba Medical Center, Ramat Gan, Israel., Frishman L; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Sheba Medical Center, Ramat Gan, Israel., Birger Y; Sheba Medical Center, Ramat Gan, Israel.; Schneider Children's Medical Center of Israel, Petach Tiqva, Israel., Eckert C; Charite University, Berlin, Germany., Tumanov S; Cancer Research UK Beatson Institute, Glasgow, UK., MacKay G; Cancer Research UK Beatson Institute, Glasgow, UK., Kamphorst JJ; Cancer Research UK Beatson Institute, Glasgow, UK.; Rheos Medicines, Cambridge, MA, USA., Herzyk P; Glasgow Polyomics, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Institute of Molecular, Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Fernández-García J; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Abramovich I; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Mor I; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Bardini M; Centro Ricerca Tettamanti, Fondazione MBBM, Universita degli Studi di Milano-Bicocca, Monza, Italy., Barin E; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Janaki-Raman S; Donald B. and Catherine C. Marron Cancer Metabolism Center, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cross JR; Donald B. and Catherine C. Marron Cancer Metabolism Center, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kharas MG; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gottlieb E; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. e.gottlieb@technion.ac.il., Izraeli S; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. sizraeli@gmail.com.; Sheba Medical Center, Ramat Gan, Israel. sizraeli@gmail.com.; Schneider Children's Medical Center of Israel, Petach Tiqva, Israel. sizraeli@gmail.com.; Beckman Research Institute, City of Hope, Duarte, CA, USA. sizraeli@gmail.com., Halsey C; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. chris.halsey@glasgow.ac.uk.
Source: Nature cancer [Nat Cancer] 2020 Oct; Vol. 1 (10), pp. 998-1009. Date of Electronic Publication: 2020 Sep 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer
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  Data: Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase.
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