Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.
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| Title: | Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. |
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| Authors: | Jones G; Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Trajanoska K; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Santanasto AJ; University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA., Stringa N; Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Kuo CL; Biostatistics Center, Connecticut Convergence Institute for Translation in Regenerative Engineering, UConn Health, Farmington, CT, USA., Atkins JL; Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Lewis JR; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; School fo Public Health University of Sydney, Sydney, NSW, Australia.; Medical School, University of Western Australia, Crawley, WA, Australia., Duong T; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hong S; Lübeck Interdisciplinary Plattform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany., Biggs ML; Cardiovascular Health Research Unit, Department of Medicine, and Department of Biostatistics, University of Washington, Seattle, WA, USA., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Sarnowski C; Biostatistics Department, Boston University School of Public Health, Boston, MA, USA., Lunetta KL; Biostatistics Department, Boston University School of Public Health, Boston, MA, USA., Tanaka T; Longitudinal Study Section, Translational Gerontology branch, National Institute on Aging, Baltimore, MD, USA., Wojczynski MK; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Cvejkus R; University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Ghasemi S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Yang J; Rush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Zillikens MC; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Walter S; Department of Medicine and Public Health, Rey Juan Carlos University, Madrid, Spain.; CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain., Sicinski K; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA., Kague E; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK., Ackert-Bicknell CL; Department of Orthopedics, University of Colorado, Aurora, CO, USA., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Windham BG; Department of Medicine/Geriatrics, University of Mississippi School of Medicine, Jackson, MS, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Grove ML; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Spira D; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Department of Endocrinology and Metabolism, Berlin, Germany., Demuth I; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Department of Endocrinology and Metabolism, Berlin, Germany.; Charité - Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany., van der Velde N; Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., de Groot LCPGM; Wageningen University, Division of Human Nutrition, PO-box 17, 6700 AA, Wageningen, The Netherlands., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Odden MC; Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA., Fohner AE; Department of Epidemiology and Institute of Public Genetics, University of Washington, Seattle, WA, USA., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., van Schoor NM; Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Huisman M; Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Tan Q; Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern Denmark, Odense, Denmark., Zmuda J; University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Karlsson M; Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden., Bennett DA; Rush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Buchman AS; Rush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., De Jager PL; Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Uitterlinden AG; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Kocher T; Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Rodriguéz-Mañas L; CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.; Department of Geriatrics, Getafe University Hospital, Getafe, Spain., García FJ; CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.; Department of Geriatrics, Hospital Virgen del Valle, Complejo Hospitalario de Toledo, Toledo, Spain., Carnicero JA; CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain., Herd P; Professor of Public Policy, Georgetown University, Washington, DC, USA., Bertram L; Lübeck Interdisciplinary Plattform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden., Murabito JM; Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA., Melzer D; Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Kuchel GA; Center on Aging, University of Connecticut Health, 263 Farmington Avenue, Farmington, CT, 06030, USA., Ferrucci L; National Institute on Aging, Baltimore, MD, USA., Karasik D; Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel., Rivadeneira F; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Kiel DP; Marcus Institute for Aging Research, Hebrew SeniorLife and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Broad Institute of MIT & Harvard, Boston, MA, USA., Pilling LC; Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. L.Pilling@exeter.ac.uk. |
| Source: | Nature communications [Nat Commun] 2021 Jan 28; Vol. 12 (1), pp. 654. Date of Electronic Publication: 2021 Jan 28. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-021-20918-w |
