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Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.

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Title: Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Authors: Ogden TEH; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK., Yang JC; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK., Schimpl M; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Easton LE; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK., Underwood E; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Rawlins PB; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., McCauley MM; Department of Biochemistry & Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA., Langelier MF; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada., Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada., Embrey KJ; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Neuhaus D; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Source: Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 2266-2288.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
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