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A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart.

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Title: A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart.
Authors: Bose HS; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.) bose_hs@mercer.edu., Whittal RM; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.)., Marshall B; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.)., Rajapaksha M; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.)., Wang NP; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.)., Bose M; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.) bose_hs@mercer.edu., Perry EW; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.)., Zhao ZQ; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.)., Miller WL; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.).
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Apr; Vol. 377 (1), pp. 108-120. Date of Electronic Publication: 2021 Feb 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
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  Data: A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart.
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  Data: <searchLink fieldCode="AU" term="%22Bose+HS%22">Bose HS</searchLink>; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.) bose_hs@mercer.edu.<br /><searchLink fieldCode="AU" term="%22Whittal+RM%22">Whittal RM</searchLink>; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.).<br /><searchLink fieldCode="AU" term="%22Marshall+B%22">Marshall B</searchLink>; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.).<br /><searchLink fieldCode="AU" term="%22Rajapaksha+M%22">Rajapaksha M</searchLink>; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.).<br /><searchLink fieldCode="AU" term="%22Wang+NP%22">Wang NP</searchLink>; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.).<br /><searchLink fieldCode="AU" term="%22Bose+M%22">Bose M</searchLink>; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.) bose_hs@mercer.edu.<br /><searchLink fieldCode="AU" term="%22Perry+EW%22">Perry EW</searchLink>; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.).<br /><searchLink fieldCode="AU" term="%22Zhao+ZQ%22">Zhao ZQ</searchLink>; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.).<br /><searchLink fieldCode="AU" term="%22Miller+WL%22">Miller WL</searchLink>; Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia (H.S.B., M.R., N.P.W., Z.-Q.Z.); Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada (R.M.W.); Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Georgia (B.M., E.W.P.); Curtiss Healthcare, University of Florida Innovate Sid Martin Biotechbology Incubator, Gainesville, Florida (M.B.); Anderson Cancer Institute, Savannah, Georgia (H.S.B.); and Department of Pediatrics and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California (W.L.M.).
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