Molecular response and quality of life in chronic myeloid leukemia patients treated with intermittent TKIs: First interim analysis of OPTkIMA study.

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Title: Molecular response and quality of life in chronic myeloid leukemia patients treated with intermittent TKIs: First interim analysis of OPTkIMA study.
Authors: Malagola M; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy., Iurlo A; Hematology Division, Foundation IRCCS Ca, Granda Ospedale Maggiore Policlinico, Milan, Italy., Abruzzese E; Division of Hematology, S. Eugenio Hospital, ASL ROMA2, Tor Vergata University, Roma, Italy., Bonifacio M; Department of Medicine, Section of Hematology, University of Verona, Verona, Italy., Stagno F; Department of Hematology, University of Catania, Catania, Italy., Binotto G; Hematology and Clinical Immunology, Department of Medicine, Padua School of Medicine, Padua, Italy., D'Adda M; Division of Hematology, ASST-Spedali Civili di Brescia, Brescia, Italy., Lunghi M; Division of Hematology, Department of Translation Medicine, University of Eastern Piedmont, Novara, Italy., Crugnola M; Hematology Unit and BMT Center Azienda Ospedaliero Universitaria Parma, Parma, Italy., Ferrari ML; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Lunghi F; Hematology and Bone Marrow Transplantation (BMT) Unit, San Raffaele Scientific Institute, Milan, Italy., Castagnetti F; Hematology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), S. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy., Rosti G; IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Lemoli RM; Clinic of Hematology, University of Genoa, Ospedale Policlinico S. Martino, IRCCS, Genoa, Italy., Sancetta R; Hematology Unit, Dell'Angelo Hospital, Venezia-Mestre, Italy., Coppi MR; Haematology and BMT Unit 'Antonio Perrino' Hospital, Brindisi, Italy., Corsetti MT; Hematology Division, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy., Rege Cambrin G; Medicina Interna a Indirizzo Ematologico, Ospedale San Luigi, Orbassano, Italy., Romano A; IRCCS Regina Elena National Cancer Institute-Rome, Roma, Italy., Tiribelli M; Division of Hematology and BMT, Department of Medical and Morphological Researches, University of Udine, Udine, Italy., Russo Rossi A; Hematology and Transplants Unit, University of Bari, Bari, Italy., Russo S; Division of Hematology, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva, Policlinico G Martino, University of Messina, Messina, Italy., Aprile L; SC Ematologia, Ospedale S.G.Moscati, Taranto, Italy., Bocchia M; Hematology Unit, Department of Medicine, Surgery and Neuroscience, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy., Gandolfi L; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy., Farina M; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy., Bernardi S; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy.; CREA Laboratory (Hematological-Research AIL Centre), ASST-Spedali Civili Brescia, Brescia, Italy., Polverelli N; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy., Roccaro AM; Clinical Research Development and Phase I Unit, ASST-Spedali Civili Brescia, Brescia, Italy., De Vivo A; Hematology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), S. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy., Baccarani M; University of Bologna, Bologna, Italy., Russo D; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy.
Source: Cancer medicine [Cancer Med] 2021 Mar; Vol. 10 (5), pp. 1726-1737. Date of Electronic Publication: 2021 Feb 16.
Publication Type: Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE
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  Data: Molecular response and quality of life in chronic myeloid leukemia patients treated with intermittent TKIs: First interim analysis of OPTkIMA study.
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  Data: <searchLink fieldCode="AU" term="%22Malagola+M%22">Malagola M</searchLink>; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Iurlo+A%22">Iurlo A</searchLink>; Hematology Division, Foundation IRCCS Ca, Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Abruzzese+E%22">Abruzzese E</searchLink>; Division of Hematology, S. Eugenio Hospital, ASL ROMA2, Tor Vergata University, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Bonifacio+M%22">Bonifacio M</searchLink>; Department of Medicine, Section of Hematology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Stagno+F%22">Stagno F</searchLink>; Department of Hematology, University of Catania, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Binotto+G%22">Binotto G</searchLink>; Hematology and Clinical Immunology, Department of Medicine, Padua School of Medicine, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22D'Adda+M%22">D'Adda M</searchLink>; Division of Hematology, ASST-Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Lunghi+M%22">Lunghi M</searchLink>; Division of Hematology, Department of Translation Medicine, University of Eastern Piedmont, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Crugnola+M%22">Crugnola M</searchLink>; Hematology Unit and BMT Center Azienda Ospedaliero Universitaria Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrari+ML%22">Ferrari ML</searchLink>; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Lunghi+F%22">Lunghi F</searchLink>; Hematology and Bone Marrow Transplantation (BMT) Unit, San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Castagnetti+F%22">Castagnetti F</searchLink>; Hematology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), S. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Rosti+G%22">Rosti G</searchLink>; IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Lemoli+RM%22">Lemoli RM</searchLink>; Clinic of Hematology, University of Genoa, Ospedale Policlinico S. Martino, IRCCS, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Sancetta+R%22">Sancetta R</searchLink>; Hematology Unit, Dell'Angelo Hospital, Venezia-Mestre, Italy.<br /><searchLink fieldCode="AU" term="%22Coppi+MR%22">Coppi MR</searchLink>; Haematology and BMT Unit 'Antonio Perrino' Hospital, Brindisi, Italy.<br /><searchLink fieldCode="AU" term="%22Corsetti+MT%22">Corsetti MT</searchLink>; Hematology Division, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Rege+Cambrin+G%22">Rege Cambrin G</searchLink>; Medicina Interna a Indirizzo Ematologico, Ospedale San Luigi, Orbassano, Italy.<br /><searchLink fieldCode="AU" term="%22Romano+A%22">Romano A</searchLink>; IRCCS Regina Elena National Cancer Institute-Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Tiribelli+M%22">Tiribelli M</searchLink>; Division of Hematology and BMT, Department of Medical and Morphological Researches, University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+Rossi+A%22">Russo Rossi A</searchLink>; Hematology and Transplants Unit, University of Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+S%22">Russo S</searchLink>; Division of Hematology, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva, Policlinico G Martino, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Aprile+L%22">Aprile L</searchLink>; SC Ematologia, Ospedale S.G.Moscati, Taranto, Italy.<br /><searchLink fieldCode="AU" term="%22Bocchia+M%22">Bocchia M</searchLink>; Hematology Unit, Department of Medicine, Surgery and Neuroscience, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Gandolfi+L%22">Gandolfi L</searchLink>; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Farina+M%22">Farina M</searchLink>; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+S%22">Bernardi S</searchLink>; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy.; CREA Laboratory (Hematological-Research AIL Centre), ASST-Spedali Civili Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Polverelli+N%22">Polverelli N</searchLink>; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Roccaro+AM%22">Roccaro AM</searchLink>; Clinical Research Development and Phase I Unit, ASST-Spedali Civili Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22De+Vivo+A%22">De Vivo A</searchLink>; Hematology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), S. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Baccarani+M%22">Baccarani M</searchLink>; University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+D%22">Russo D</searchLink>; Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili, Brescia, Italy.
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