Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease.
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| Title: | Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease. |
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| Authors: | Horowitz JE; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Kosmicki JA; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Damask A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Sharma D; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Roberts GHL; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Justice AE; Geisinger, Danville, PA, 17822, USA., Banerjee N; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Coignet MV; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Yadav A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Leader JB; Geisinger, Danville, PA, 17822, USA., Marcketta A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Park DS; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Lanche R; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Maxwell E; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Knight SC; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Bai X; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Guturu H; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Sun D; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Baltzell A; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Kury FSP; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Backman JD; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Girshick AR; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., O'Dushlaine C; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., McCurdy SR; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Partha R; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Mansfield AJ; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Turissini DA; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Li AH; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Zhang M; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Mbatchou J; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Watanabe K; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Gurski L; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., McCarthy SE; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Kang HM; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Dobbyn L; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Stahl E; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Sirugo G; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Ritchie MD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Jones M; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Balasubramanian S; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Siminovitch K; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Salerno WJ; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Shuldiner AR; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Mirshahi T; Geisinger, Danville, PA, 17822, USA., Locke AE; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Marchini J; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Overton JD; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Carey DJ; Geisinger, Danville, PA, 17822, USA., Habegger L; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Cantor MN; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Rand KA; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Hong EL; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Reid JG; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Ball CA; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Baras A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Abecasis GR; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Ferreira MA; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA. |
| Corporate Authors: | Regeneron Genetics Center |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2021 Jun 10. Date of Electronic Publication: 2021 Jun 10. |
| Publication Type: | Preprint; Journal Article |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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