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Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial.

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Title: Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial.
Authors: Balcells ME; Department of Infectious Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Rojas L; Department of Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Program of Pharmacology and Toxicology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Le Corre N; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Diagnostic Virology Laboratory, Red de Salud UC CHRISTUS, Santiago, Chile., Martínez-Valdebenito C; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Diagnostic Virology Laboratory, Red de Salud UC CHRISTUS, Santiago, Chile., Ceballos ME; Department of Infectious Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Ferrés M; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Diagnostic Virology Laboratory, Red de Salud UC CHRISTUS, Santiago, Chile., Chang M; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Vizcaya C; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Mondaca S; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Huete Á; Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Castro R; Department of Intensive Care Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Sarmiento M; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Villarroel L; Department of Public Health, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Pizarro A; Department of Infectious Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Ross P; Department of Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Santander J; Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Lara B; Emergency Medicine Section, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Ferrada M; Clinical Research Center, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Vargas-Salas S; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Beltrán-Pavez C; Laboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.; HIV/AIDS Work Group, Faculty of Medicine, Universidad de Chile, Santiago, Chile., Soto-Rifo R; Laboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.; HIV/AIDS Work Group, Faculty of Medicine, Universidad de Chile, Santiago, Chile., Valiente-Echeverría F; Laboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.; HIV/AIDS Work Group, Faculty of Medicine, Universidad de Chile, Santiago, Chile., Caglevic C; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile., Mahave M; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile., Selman C; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile., Gazitúa R; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile., Briones JL; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile., Villarroel-Espindola F; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.; Translational Medicine Research Laboratory, Fundación Arturo López Pérez, Santiago, Chile., Balmaceda C; Health Technology Assessment Unit, Clinical Research Center, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Espinoza MA; Department of Public Health, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Pereira J; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Nervi B; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Source: PLoS medicine [PLoS Med] 2021 Mar 03; Vol. 18 (3), pp. e1003415. Date of Electronic Publication: 2021 Mar 03 (Print Publication: 2021).
Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101231360 Publication Model: eCollection Cited Medium: Internet ISSN: 1549-1676 (Electronic) Linking ISSN: 15491277 NLM ISO Abbreviation: PLoS Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Balcells+ME%22">Balcells ME</searchLink>; Department of Infectious Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Rojas+L%22">Rojas L</searchLink>; Department of Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Program of Pharmacology and Toxicology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Le+Corre+N%22">Le Corre N</searchLink>; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Diagnostic Virology Laboratory, Red de Salud UC CHRISTUS, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Martínez-Valdebenito+C%22">Martínez-Valdebenito C</searchLink>; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Diagnostic Virology Laboratory, Red de Salud UC CHRISTUS, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Ceballos+ME%22">Ceballos ME</searchLink>; Department of Infectious Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Ferrés+M%22">Ferrés M</searchLink>; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Diagnostic Virology Laboratory, Red de Salud UC CHRISTUS, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Chang+M%22">Chang M</searchLink>; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Vizcaya+C%22">Vizcaya C</searchLink>; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Mondaca+S%22">Mondaca S</searchLink>; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Huete+Á%22">Huete Á</searchLink>; Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Castro+R%22">Castro R</searchLink>; Department of Intensive Care Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Sarmiento+M%22">Sarmiento M</searchLink>; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Villarroel+L%22">Villarroel L</searchLink>; Department of Public Health, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Pizarro+A%22">Pizarro A</searchLink>; Department of Infectious Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Ross+P%22">Ross P</searchLink>; Department of Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Santander+J%22">Santander J</searchLink>; Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Lara+B%22">Lara B</searchLink>; Emergency Medicine Section, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Ferrada+M%22">Ferrada M</searchLink>; Clinical Research Center, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Vargas-Salas+S%22">Vargas-Salas S</searchLink>; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Beltrán-Pavez+C%22">Beltrán-Pavez C</searchLink>; Laboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.; HIV/AIDS Work Group, Faculty of Medicine, Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Soto-Rifo+R%22">Soto-Rifo R</searchLink>; Laboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.; HIV/AIDS Work Group, Faculty of Medicine, Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Valiente-Echeverría+F%22">Valiente-Echeverría F</searchLink>; Laboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.; HIV/AIDS Work Group, Faculty of Medicine, Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Caglevic+C%22">Caglevic C</searchLink>; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Mahave+M%22">Mahave M</searchLink>; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Selman+C%22">Selman C</searchLink>; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Gazitúa+R%22">Gazitúa R</searchLink>; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Briones+JL%22">Briones JL</searchLink>; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Villarroel-Espindola+F%22">Villarroel-Espindola F</searchLink>; Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.; Translational Medicine Research Laboratory, Fundación Arturo López Pérez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Balmaceda+C%22">Balmaceda C</searchLink>; Health Technology Assessment Unit, Clinical Research Center, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Espinoza+MA%22">Espinoza MA</searchLink>; Department of Public Health, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Pereira+J%22">Pereira J</searchLink>; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Nervi+B%22">Nervi B</searchLink>; Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
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