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Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.

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Title: Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.
Authors: Bach K; University of Cambridge, Department of Pharmacology, Cambridge, UK.; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK., Pensa S; University of Cambridge, Department of Pharmacology, Cambridge, UK.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK., Zarocsinceva M; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Kania K; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK., Stockis J; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK., Pinaud S; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK., Lazarus KA; University of Cambridge, Department of Pharmacology, Cambridge, UK.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK., Shehata M; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK., Simões BM; Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, Manchester, UK., Greenhalgh AR; Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, Manchester, UK., Howell SJ; Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, Manchester, UK.; Department of Medical Oncology, Christie NHS Foundation Trust, Manchester, UK., Clarke RB; Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, Manchester, UK., Caldas C; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK., Halim TYF; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK., Marioni JC; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK. John.Marioni@cruk.cam.ac.uk.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. John.Marioni@cruk.cam.ac.uk.; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK. John.Marioni@cruk.cam.ac.uk., Khaled WT; University of Cambridge, Department of Pharmacology, Cambridge, UK. wtk22@cam.ac.uk.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK. wtk22@cam.ac.uk.; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. wtk22@cam.ac.uk.
Source: Nature communications [Nat Commun] 2021 Mar 09; Vol. 12 (1), pp. 1502. Date of Electronic Publication: 2021 Mar 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.
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  Data: <searchLink fieldCode="AU" term="%22Bach+K%22">Bach K</searchLink>; University of Cambridge, Department of Pharmacology, Cambridge, UK.; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pensa+S%22">Pensa S</searchLink>; University of Cambridge, Department of Pharmacology, Cambridge, UK.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Zarocsinceva+M%22">Zarocsinceva M</searchLink>; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kania+K%22">Kania K</searchLink>; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Stockis+J%22">Stockis J</searchLink>; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pinaud+S%22">Pinaud S</searchLink>; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lazarus+KA%22">Lazarus KA</searchLink>; University of Cambridge, Department of Pharmacology, Cambridge, UK.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Shehata+M%22">Shehata M</searchLink>; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Simões+BM%22">Simões BM</searchLink>; Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Greenhalgh+AR%22">Greenhalgh AR</searchLink>; Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Howell+SJ%22">Howell SJ</searchLink>; Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, Manchester, UK.; Department of Medical Oncology, Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Clarke+RB%22">Clarke RB</searchLink>; Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Caldas+C%22">Caldas C</searchLink>; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Halim+TYF%22">Halim TYF</searchLink>; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Marioni+JC%22">Marioni JC</searchLink>; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK. John.Marioni@cruk.cam.ac.uk.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. John.Marioni@cruk.cam.ac.uk.; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK. John.Marioni@cruk.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Khaled+WT%22">Khaled WT</searchLink>; University of Cambridge, Department of Pharmacology, Cambridge, UK. wtk22@cam.ac.uk.; Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK. wtk22@cam.ac.uk.; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. wtk22@cam.ac.uk.
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