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Machine Learning-based Prediction Model for Treatment of Acromegaly With First-generation Somatostatin Receptor Ligands.

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Title: Machine Learning-based Prediction Model for Treatment of Acromegaly With First-generation Somatostatin Receptor Ligands.
Authors: Wildemberg LE; Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho-Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Neuroendocrine Unit-Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde , Rio de Janeiro, RJ, Brazil., da Silva Camacho AH; Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, RJ, Brazil., Miranda RL; Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, RJ, Brazil., Elias PCL; Division of Endocrinology-Department of Internal Medicine, Ribeirao Preto Medical School-University of Sao Paulo, São Paulo, SP, Brazil., de Castro Musolino NR; Neuroendocrine Unit, Division of Functional Neurosurgery, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Nazato D; Neuroendocrine Unit-Division of Endocrinology and Metabolism-Escola Paulista de Medicina-Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil., Jallad R; Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, SP, Brazil.; Cellular and Molecular Endocrinology Laboratory/LIM25, Discipline of Endocrinology, Hospital das Clinicas HCFMUSP, Faculty of Medicine, University of Sao Paulo, São Paulo, SP, Brazil., Huayllas MKP; Neuroendocrinology and Neurosurgery unit Hospital Brigadeiro, São Paulo, SP, Brazil., Mota JIS; Endocrinology and Metabolism Unit, Hospital Geral de Fortaleza, Secretaria Estadual de Saúde, Fortaleza, CE, Brazil., Almeida T; Division of Endocrinology, Hospital de Clinicas de Porto Alegre (UFRGS), Porto Alegre, RS, Brazil., Portes E; Institute of Medical Assistance to the State Public Hospital, São Paulo, SP, Brazil., Ribeiro-Oliveira A; Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Vilar L; Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, Federal University of Pernambuco Medical School, Recife, PE, Brazil., Boguszewski CL; Endocrine Division (SEMPR), Department of Internal Medicine, Universidade Federal do Parana, Curitiba, PR, Brazil., Winter Tavares AB; Endocrine Unit-Department of Internal Medicine, Faculty of Medical Sciences, Universidade do Estado do Rio de Janeiro, RJ, Brazil., Nunes-Nogueira VS; Department of Internal Medicine, São Paulo State University/UNESP, Medical School, Botucatu, SP, Brazil., Mazzuco TL; Division of Endocrinology of Medical Clinical Department, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil., Rech CGSL; Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil., Marques NV; Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho-Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Chimelli L; Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, RJ, Brazil., Czepielewski M; Division of Endocrinology, Hospital de Clinicas de Porto Alegre (UFRGS), Porto Alegre, RS, Brazil., Bronstein MD; Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, SP, Brazil.; Cellular and Molecular Endocrinology Laboratory/LIM25, Discipline of Endocrinology, Hospital das Clinicas HCFMUSP, Faculty of Medicine, University of Sao Paulo, São Paulo, SP, Brazil., Abucham J; Neuroendocrine Unit-Division of Endocrinology and Metabolism-Escola Paulista de Medicina-Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil., de Castro M; Division of Endocrinology-Department of Internal Medicine, Ribeirao Preto Medical School-University of Sao Paulo, São Paulo, SP, Brazil., Kasuki L; Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho-Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Neuroendocrine Unit-Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde , Rio de Janeiro, RJ, Brazil., Gadelha M; Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho-Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Neuroendocrine Unit-Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde , Rio de Janeiro, RJ, Brazil.; Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, RJ, Brazil.
Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Jun 16; Vol. 106 (7), pp. 2047-2056.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE
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  Data: Machine Learning-based Prediction Model for Treatment of Acromegaly With First-generation Somatostatin Receptor Ligands.
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  Data: <searchLink fieldCode="AU" term="%22Wildemberg+LE%22">Wildemberg LE</searchLink>; Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho-Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Neuroendocrine Unit-Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde , Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Camacho+AH%22">da Silva Camacho AH</searchLink>; Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Miranda+RL%22">Miranda RL</searchLink>; Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Elias+PCL%22">Elias PCL</searchLink>; Division of Endocrinology-Department of Internal Medicine, Ribeirao Preto Medical School-University of Sao Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Castro+Musolino+NR%22">de Castro Musolino NR</searchLink>; Neuroendocrine Unit, Division of Functional Neurosurgery, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Nazato+D%22">Nazato D</searchLink>; Neuroendocrine Unit-Division of Endocrinology and Metabolism-Escola Paulista de Medicina-Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Jallad+R%22">Jallad R</searchLink>; Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, SP, Brazil.; Cellular and Molecular Endocrinology Laboratory/LIM25, Discipline of Endocrinology, Hospital das Clinicas HCFMUSP, Faculty of Medicine, University of Sao Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Huayllas+MKP%22">Huayllas MKP</searchLink>; Neuroendocrinology and Neurosurgery unit Hospital Brigadeiro, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Mota+JIS%22">Mota JIS</searchLink>; Endocrinology and Metabolism Unit, Hospital Geral de Fortaleza, Secretaria Estadual de Saúde, Fortaleza, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22Almeida+T%22">Almeida T</searchLink>; Division of Endocrinology, Hospital de Clinicas de Porto Alegre (UFRGS), Porto Alegre, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Portes+E%22">Portes E</searchLink>; Institute of Medical Assistance to the State Public Hospital, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Ribeiro-Oliveira+A%22">Ribeiro-Oliveira A</searchLink>; Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.<br /><searchLink fieldCode="AU" term="%22Vilar+L%22">Vilar L</searchLink>; Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, Federal University of Pernambuco Medical School, Recife, PE, Brazil.<br /><searchLink fieldCode="AU" term="%22Boguszewski+CL%22">Boguszewski CL</searchLink>; Endocrine Division (SEMPR), Department of Internal Medicine, Universidade Federal do Parana, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Winter+Tavares+AB%22">Winter Tavares AB</searchLink>; Endocrine Unit-Department of Internal Medicine, Faculty of Medical Sciences, Universidade do Estado do Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Nunes-Nogueira+VS%22">Nunes-Nogueira VS</searchLink>; Department of Internal Medicine, São Paulo State University/UNESP, Medical School, Botucatu, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Mazzuco+TL%22">Mazzuco TL</searchLink>; Division of Endocrinology of Medical Clinical Department, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Rech+CGSL%22">Rech CGSL</searchLink>; Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Marques+NV%22">Marques NV</searchLink>; Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho-Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Chimelli+L%22">Chimelli L</searchLink>; Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Czepielewski+M%22">Czepielewski M</searchLink>; Division of Endocrinology, Hospital de Clinicas de Porto Alegre (UFRGS), Porto Alegre, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Bronstein+MD%22">Bronstein MD</searchLink>; Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, SP, Brazil.; Cellular and Molecular Endocrinology Laboratory/LIM25, Discipline of Endocrinology, Hospital das Clinicas HCFMUSP, Faculty of Medicine, University of Sao Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Abucham+J%22">Abucham J</searchLink>; Neuroendocrine Unit-Division of Endocrinology and Metabolism-Escola Paulista de Medicina-Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Castro+M%22">de Castro M</searchLink>; 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