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Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.

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Title: Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.
Authors: Simcoe M; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.; Department of Ophthalmology, King's College London, London, UK., Valdes A; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK., Liu F; Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Furlotte NA; 23andMe Inc., Sunnyvale, CA, USA., Evans DM; University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences Bristol Medical School University of Bristol, Bristol, UK., Ring SM; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences Bristol Medical School University of Bristol, Bristol, UK., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences Bristol Medical School University of Bristol, Bristol, UK., Duffy DL; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Zhu G; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Gordon SD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Vuckovic D; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy.; Epidemiology and Biostatistics Department, Faculty of Medicine, School of Public Health, Imperial College London, London, UK., Girotto G; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Sala C; Division of Genetics of Common Disorders, S. Raffaele Scientific Institute, Milan, Italy., Catamo E; Department of Medical Sciences, University of Trieste, Trieste, Italy., Concas MP; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Brumat M; Department of Medical Sciences, University of Trieste, Trieste, Italy., Gasparini P; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Toniolo D; Division of Genetics of Common Disorders, S. Raffaele Scientific Institute, Milan, Italy., Cocca M; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Robino A; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Yazar S; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia., Hewitt A; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia.; Centre for Eye Research Australia, University of Melbourne, Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.; School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia., Wu W; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Hammond CJ; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.; Department of Ophthalmology, King's College London, London, UK., Shi Y; Singapore Eye Research Institute, Singapore National Eye Center, Singapore., Chen Y; Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Zeng C; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China., Klaver CCW; Department of Ophthalmology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, Netherlands., Uitterlinden AG; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., Hamer MA; Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Nijsten T; Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., Han J; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA., Mackey DA; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Center, Singapore.; Duke-NUS Medical School, Singapore., Hinds DA; 23andMe Inc., Sunnyvale, CA, USA., Spector TD; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK., Kayser M; Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands. pirro.hysi@kcl.ac.uk., Hysi PG; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK. pirro.hysi@kcl.ac.uk.; Department of Ophthalmology, King's College London, London, UK.
Corporate Authors: 23andMe Research Team, International Visible Trait Genetics Consortium
Source: Science advances [Sci Adv] 2021 Mar 10; Vol. 7 (11). Date of Electronic Publication: 2021 Mar 10 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.
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  Data: <searchLink fieldCode="AU" term="%22Simcoe+M%22">Simcoe M</searchLink>; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.; Department of Ophthalmology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Valdes+A%22">Valdes A</searchLink>; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Furlotte+NA%22">Furlotte NA</searchLink>; 23andMe Inc., Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Evans+DM%22">Evans DM</searchLink>; University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Hemani+G%22">Hemani G</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences Bristol Medical School University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Ring+SM%22">Ring SM</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences Bristol Medical School University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Smith+GD%22">Smith GD</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences Bristol Medical School University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Duffy+DL%22">Duffy DL</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Zhu+G%22">Zhu G</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Gordon+SD%22">Gordon SD</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Medland+SE%22">Medland SE</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Vuckovic+D%22">Vuckovic D</searchLink>; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy.; Epidemiology and Biostatistics Department, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Girotto+G%22">Girotto G</searchLink>; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Sala+C%22">Sala C</searchLink>; Division of Genetics of Common Disorders, S. 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