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Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.

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Title: Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.
Authors: Grohmann C; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia. grohmann.c@wehi.edu.au.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia. grohmann.c@wehi.edu.au., Walker F; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.; Ludwig Institute for Cancer Research, Melbourne, VIC, 3000, Australia., Devlin M; Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre building, Melbourne, 3000, Australia.; Cancer Therapeutics CRC, Melbourne, VIC, 3000, Australia., Luo MX; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Chüeh AC; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.; Cancer Therapeutics CRC, Melbourne, VIC, 3000, Australia., Doherty J; Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre building, Melbourne, 3000, Australia.; Cancer Therapeutics CRC, Melbourne, VIC, 3000, Australia., Vaillant F; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Ho GY; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Wakefield MJ; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.; The University of Melbourne, Department of Obstetrics and Gynaecology, Parkville, VIC, 3050, Australia., Weeden CE; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Kamili A; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.; School of Women's and Children's Health, UNSW, Sydney, NSW, 2052, Australia., Murray J; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia., Po'uha ST; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia., Weinstock J; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.; Ludwig Institute for Cancer Research, Melbourne, VIC, 3000, Australia., Kane SR; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Faux MC; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Broekhuizen E; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Zheng Y; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Shield-Artin K; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Kershaw NJ; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.; Ludwig Institute for Cancer Research, Melbourne, VIC, 3000, Australia., Tan CW; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Witchard HM; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia., Ebert G; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Clayton, VIC, 3052, Australia., Street I; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; Cancer Therapeutics CRC, Melbourne, VIC, 3000, Australia., Kavallaris M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.; ARC Centre of Excellence in Convergent Bionano Science and Technology, Australian Centre for Nanomedicine, UNSW, Sydney, NSW, 2052, Australia., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia., Fletcher JI; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.; School of Women's and Children's Health, UNSW, Sydney, NSW, 2052, Australia., Asselin-Labat ML; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Scott CL; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.; Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre building, Melbourne, 3000, Australia.; The University of Melbourne, Department of Obstetrics and Gynaecology, Parkville, VIC, 3050, Australia., Visvader JE; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Lindeman GJ; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.; Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre building, Melbourne, 3000, Australia.; The University of Melbourne, Department of Medicine, Parkville, VIC, 3000, Australia., Watson KG; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia., Burgess AW; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia. tburgess@wehi.edu.au.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia. tburgess@wehi.edu.au.; Ludwig Institute for Cancer Research, Melbourne, VIC, 3000, Australia. tburgess@wehi.edu.au., Lessene G; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia. glessene@wehi.edu.au.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia. glessene@wehi.edu.au.; The University of Melbourne, Department of Pharmacology and Therapeutics, Parkville, VIC, 3050, Australia. glessene@wehi.edu.au.
Source: Cell death & disease [Cell Death Dis] 2021 Mar 12; Vol. 12 (3), pp. 268. Date of Electronic Publication: 2021 Mar 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.
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Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.; The University of Melbourne, Department of Obstetrics and Gynaecology, Parkville, VIC, 3050, Australia.<br /><searchLink fieldCode="AU" term="%22Weeden+CE%22">Weeden CE</searchLink>; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.<br /><searchLink fieldCode="AU" term="%22Kamili+A%22">Kamili A</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.; School of Women's and Children's Health, UNSW, Sydney, NSW, 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Murray+J%22">Murray J</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Po'uha+ST%22">Po'uha ST</searchLink>; 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